307299-14-5

Basic information

• Product Name: 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid
• Synonyms: 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid
• CAS NO: 307299-14-5
• Molecular Formula: C₁₅H₁₀N₂O₆
• Molecular Weight: 314.2497
• Mol File: 307299-14-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 198-200 °C(Solv: ethanol (64-17-5))
• Boiling Point: 607.2±45.0 °C(Predicted)
• Appearance: /
• Density: 1.593±0.06 g/cm3(Predicted)
• PKA: 4.22±0.10(Predicted)
• CAS DataBase Reference: 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid(307299-14-5)
• EPA Substance Registry System: 3-(6-nitro-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)propanoic acid(307299-14-5)

Safety Data

• Hazardous Substances Data: 307299-14-5(Hazardous Substances Data)

Upstream product

• 81-84-5 1,8-Naphthalic anhydride 
• 83-32-9 acenaphthene 
• 34087-02-0 2-nitro-1,8-naphthalic anhydride 
• 107-95-9 3-amino propanoic acid 
• 6642-29-1 4-nitronaphthalic-1,8-anhydride 

Downstream Products

• 1401539-55-6 C₄₅H₄₈N₄O₇PS₂⁽¹⁺⁾ 
• 1401539-54-5 C₃₅H₃₁N₃O₃P⁽¹⁺⁾ 
• 1401539-53-4 C₄₀H₃₉N₃O₆PS₂⁽¹⁺⁾ 

Relevant articles and documents

The synthesis and fluorescence of novel N-substituted-1,8-naphthylimides

(Chemical Equation Presented) The synthesis and characterisation of a series of novel 4-acylamino and 4-alkylamino-N-1,8-naphthalimides is described. The UV-visible absorption and emission properties of the compounds are reported. Significant solvent effects are noted for 4-n-butyl-9-n-butyl-1,8- naphthylimide. The incorporation of acetyl and chloroacetyl groups into the 4-substituent markedly increases the fluorescence quantum yield compared with 4-alkylamino substituemnts.

Tetravalent platinum naphthalimide complex, preparation method and application thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a tetravalent platinum naphthalimide complex, a preparation method and application thereof. The tetravalent platinum naphthalimide complex has good anti-tumor activity, which is better than that of cis-platinum and oxaliplatin, and the tetravalent platinum naphthalimide complex has better stability than bivalent platinum like cis-platinum, carboplatin and oxaliplatin. According to the invention, the naphthalimide modified tetravalent platinum has good targeting performance on tumor cells, high selectivity on tumor cells is improved, and different from a classic divalent platinum drug, the complex provided by the invention regulates and controls subcellular organelles and cell nucleus functionsto reverse drug resistance by targeting a tumor high polyamine microenvironment, and relieves immunosuppression of T cells around tumors at the same time. The complex provided by the invention also solves the problems of poor solubility, tedious clinical compatibility, poor patient immunity in clinical application of chemotherapeutic drugs and the like of previous bivalent platinum antitumor drugs, and has good fat solubility and water solubility.

NITROGEN-BASED HOMO-CAMPTOTHECIN DERIVATIVES

(20) esters of camptothecin analogs are provided. The compounds are (20) esters of an aminoalkanoic acid or an imidoalkanoic acid and homocamptothecin, which is optionally substituted at the 7, 9, 10, 11, and 12 positions of the homocamptothecin ring. The