30766-12-2

Basic information

• Product Name: 5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: methyl 5-hydroxypicolinate;H57157;Methyl 5-hydroxypyridine-2-carboxylate ,97%;Methyl 5-hydroxypyridine-2-carboxylate;5-Hydroxy-2-pyridinecarboxylic acid methyl ester;2-Pyridinecarboxylic acid, 5-hydroxy-, methyl ester;Methyl 5-hydroxypyridine-...;Methyl 5-hydroxypicolinate, 5-Hydroxy-2-(methoxycarbonyl)pyridine
• CAS NO: 30766-12-2
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Mol File: 30766-12-2.mol
• Article Data: 17

Chemical Properties

• Melting Point: 193.5-195.5℃
• Boiling Point: 374.2 °C at 760 mmHg
• Flash Point: 180.1 °C
• Appearance: /
• Density: 1.287 g/cm³
• Vapor Pressure: 3.95E-06mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.29±0.10(Predicted)
• CAS DataBase Reference: 5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(30766-12-2)
• EPA Substance Registry System: 5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER(30766-12-2)

Safety Data

• Statements: 20/21/22
• Safety Statements: 24/25-36/37
• Hazardous Substances Data: 30766-12-2(Hazardous Substances Data)

Usage

Chemical Properties

Yellow solid

InChI:InChI=1/C7H7NO3/c1-11-7(10)6-3-2-5(9)4-8-6/h2-4,9H,1H3

Upstream product

• 29082-92-6 5-methoxypyridine-2-carboxylic acid 
• 74386-59-7 5-benzyloxy-2-pyridinecarboxylic acid methyl ester 
• 64-17-5 ethanol 
• 67-56-1 methanol 
• 15069-92-8 5-hydroxypicolinic acid 
• 4833-91-4 5-sulfo-pyridine-2-carboxylic acid 

Downstream Products

• 856835-98-8 5-hydroxy-pyridine-2-carboxylic acid hydrazide 
• 29681-39-8 5-methoxypyridine-2-carboxylic acid methyl ester 
• 881409-53-6 5-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid 
• 1310347-56-8 5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide 
• 1310348-21-0 5-(2,2,3,3-tetrafluoro-propoxy)-pyridine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide 

Relevant articles and documents

Novel indirect AMP-activated protein kinase activators: Identification of a second-generation clinical candidate with improved physicochemical properties and reduced hERG inhibitory activity

This study reports the synthesis and evaluation of novel indirect AMP-activated protein kinase (AMPK) activators. The series of compounds selectively inhibited cell growth in several human breast cancer cell lines by activating AMPK. We performed back-up medicinal chemistry synthetic research on ASP4132, a previously reported as a compound for clinical development that acts as an indirect AMPK activator. This led to the successful identification of 4-({4-[5-({1-[(5-ethoxypyrazin-2-yl)methyl]-4-fluoropiperidin-4-yl}methoxy)-3-methylpyridine-2-carbonyl]piperazin-1-yl}methyl)benzonitrile succinate (27b), a potent, highly aqueous soluble and metabolically stable compound in human hepatocytes. Compound 27b also showed weaker human Ether-a-go-go Related Gene (hERG) inhibitory activity than that of compound 13 and ASP4132. Therefore, 27b was a promising AMPK activator and a second-generation clinical candidate for treatment for human cancer.

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

PYRIDINEAMINE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS

The present disclosure describes pyridineamine compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer, immune disorders and other diseases. Formula (I).