308266-51-5

Basic information

• Product Name: 4-azaspiro[2.4]heptan-5-one
• Synonyms: 4-azaspiro[2.4]heptan-5-one
• CAS NO: 308266-51-5
• Molecular Formula: C6H9NO
• Molecular Weight: 111.14176
• Mol File: 308266-51-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 302.6±11.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.60±0.20(Predicted)
• CAS DataBase Reference: 4-azaspiro[2.4]heptan-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-azaspiro[2.4]heptan-5-one(308266-51-5)
• EPA Substance Registry System: 4-azaspiro[2.4]heptan-5-one(308266-51-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 308266-51-5(Hazardous Substances Data)

Usage

General Description

4-Azaspiro[2.4]heptan-5-one, also known as Ropivacaine, is a local anesthetic used in various medical procedures. It belongs to the class of chemicals known as 4-Azaspiro compounds, and its structure includes a spiro ring system and a ketone functional group. Ropivacaine is commonly used for epidural and peripheral nerve block anesthesia, as it provides long-lasting pain relief without causing significant motor blockage. It works by blocking the transmission of pain signals through the nerves, making it a valuable tool in managing pain during surgery and post-operative care. Due to its relatively low toxicity and reduced risk of causing cardiac arrhythmias, Ropivacaine is often preferred over other similar local anesthetics for certain procedures.

Upstream product

• 4107-62-4 3-cyano-propionic acid methyl ester 
• 925-90-6 ethylmagnesium bromide 
• 308266-46-8 N,N-dibenzyl-1-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]cyclopropan-1-amine 
• 308266-48-0 3-[1-(N,N-dibenzylamino)cyclopropyl]propionic acid 
• 308266-50-4 3-(1-dibenzylamino-cyclopropyl)-propionic acid methyl ester 
• 308266-47-9 4-[1-(N,N-dibenzylamino)cyclopropyl]butan-2-one 
• 10137-67-4 ethyl 3-cyanopropionate 
• 308266-49-1 methyl 3-(1-aminocyclopropyl)propionate 

Relevant articles and documents

Ti-mediated chemoselective conversion of cyanoesters and cyanoamides into β-aminoesters and 1-aza-spirolactams bearing a cyclopropane ring

α-Cyanoesters or tertiary α-cyanoamides react with Grignard reagents and Ti(i-PrO)4 to afford respectively β-aminoesters or amides, bearing a cyclopropane ring. Starting from β- or γ-cyanoesters, spirocyclopropanelactams are formed via an in situ cyclopropanation-lactamization sequence.

HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS

The present disclosure describes novel heterocyclic PRMT5 inhibitors and methods for preparing them. The pharmaceutical compositions comprising such PRMT5 inhibitors and methods of using them for treating cancer, infectious diseases, and other PRMT5 associated disorders are also described.

Studies on the titanium-catalyzed cyclopropanation of nitriles

The Ti-mediated reaction of Grignard reagents with nitriles was investigated with sub-stoichiometric amounts of titanium isopropoxide. Cyanoesters were converted to spirocyclopropanelactams in good yields using as low as 0.05 eq of Ti(OiPr)sub