308273-57-6

Basic information

• Product Name: (S)-7-Chloro-3-((S)-1-phenyl-ethylamino)-heptanoic acid ethyl ester
• Synonyms: (S)-7-Chloro-3-((S)-1-phenyl-ethylamino)-heptanoic acid ethyl ester
• CAS NO: 308273-57-6
• Molecular Weight: 311.852
• Mol File: 308273-57-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-7-Chloro-3-((S)-1-phenyl-ethylamino)-heptanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-7-Chloro-3-((S)-1-phenyl-ethylamino)-heptanoic acid ethyl ester(308273-57-6)
• EPA Substance Registry System: (S)-7-Chloro-3-((S)-1-phenyl-ethylamino)-heptanoic acid ethyl ester(308273-57-6)

Safety Data

• Hazardous Substances Data: 308273-57-6(Hazardous Substances Data)

Upstream product

• 107408-35-5 ethyl (2E)-7-chlorohept-2-enoate 
• 5259-98-3 5-chloropentan-1-ol 
• 20074-80-0 5-chloro-pentanal 
• 308273-76-9 (S)-7-Chloro-3-[(4-methoxy-benzyl)-((S)-1-phenyl-ethyl)-amino]-heptanoic acid ethyl ester 

Downstream Products

• 308273-60-1 ethyl {(2S)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate 

Relevant articles and documents

Asymmetric synthesis of cyclic β-amino acids

A convenient synthesis of cyclic β-amino acid derivatives (5-, 6- and 7-rings) is achieved via a four step sequence: (i) stereoselective Michael addition of substituted α-methylbenzylamines to α,β-unsaturated chloroesters; (ii) CAN-mediated deprotection; (iii) cyclisation and (iv) α-chloroethyl chloroformate-mediated α-methylbenzylamine deprotection.