308305-50-2Relevant articles and documents
Design and synthesis of novel potent antinociceptive agents: Methyl-imidazolyl N-acylhydrazone derivatives
Figueiredo, Juliana M.,Camara, Celso De A.,Amarante, Emanuel G.,Miranda, Ana Luisa P.,Santos, Fulvia M.,Rodrigues, Carlos R.,Fraga, Carlos Alberto M.,Barreiro, Eliezer J.
, p. 2243 - 2248 (2000)
This paper describes recent results of design, synthesis and pharmacological evaluation of new N-heterocyclic functionalized N-acylhydrazone compounds, belonging to the 2-methyl-imidazolyl-3-acylhydrazone class (4a-e). These compounds were planned by applying the molecular simplification strategy to propose the structural modifications on the previously described functionalized imidazo[1,2-a]pyridine 3-acylhydrazone series (2), which presented an important analgesic profile. This new series (4) was synthesized in order to investigate the possible pharmacophoric contribution of the N-heteroaromatic ring and N-acylhydrazone moieties to the analgesic activity. Compounds 4a-b are the most potent antinociceptive agents from this series. Copyright (C) 2000 Elsevier Science Ltd.
