308789-83-5

Basic information

• Product Name: (S)-2-[((3R,3aS,6aR,9aR,9bS)-6,9-Dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethyl)-amino]-4-methylsulfanyl-butyric acid
• Synonyms: (S)-2-[((3R,3aS,6aR,9aR,9bS)-6,9-Dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethyl)-amino]-4-methylsulfanyl-butyric acid
• CAS NO: 308789-83-5
• Molecular Weight: 379.521
• Mol File: 308789-83-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[((3R,3aS,6aR,9aR,9bS)-6,9-Dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethyl)-amino]-4-methylsulfanyl-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[((3R,3aS,6aR,9aR,9bS)-6,9-Dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethyl)-amino]-4-methylsulfanyl-butyric acid(308789-83-5)
• EPA Substance Registry System: (S)-2-[((3R,3aS,6aR,9aR,9bS)-6,9-Dimethylene-2-oxo-dodecahydro-azuleno[4,5-b]furan-3-ylmethyl)-amino]-4-methylsulfanyl-butyric acid(308789-83-5)

Safety Data

• Hazardous Substances Data: 308789-83-5(Hazardous Substances Data)

Upstream product

• 63-68-3 L-methionine 
• 74299-48-2 dehydrocostus lactone 

Downstream Products

• 74299-48-2 dehydrocostus lactone 

Relevant articles and documents

Absolute stereostructures and syntheses of saussureamines A, B, C, D and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa

From the methanolic extract of the dried roots of Saussurea lappa Clarke, Saussureae Radix, five amino acid-sesquiterpene conjugates, saussureamines A, B, C, D and E, were isolated together with a lignan glycoside, (-)-massoniresinol 4-O-β-D-glucopyranoside. Their stereostructures were determined on the basis of chemical and physicochemical evidence. In addition, saussureamines and the related amino acid-sesquiterpene conjugates were synthesized using a Michael type addition reaction of amino acid to the α-methylene-γ-lactone moiety of sesquiterpenes. Saussureamines A, B and C, costunolide and dehydrocostus lactone showed a gastroprotective effect on acidified ethanol-induced gastric mucosal lesions in rats. Saussureamines A also exhibited an inhibitory effect on gastric mucosal lesions induced by water-immersion stress in mice. (C) 2000 Elsevier Science Ltd.