3094-11-9

Basic information

• Product Name: 2-Propenamide, N-(4-fluorophenyl)-2-methyl-
• CAS NO: 3094-11-9
• Molecular Formula: C10H10FNO
• Molecular Weight: 179.194
• Mol File: 3094-11-9.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: 2-Propenamide, N-(4-fluorophenyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenamide, N-(4-fluorophenyl)-2-methyl-(3094-11-9)
• EPA Substance Registry System: 2-Propenamide, N-(4-fluorophenyl)-2-methyl-(3094-11-9)

Safety Data

• Hazardous Substances Data: 3094-11-9(Hazardous Substances Data)

Usage

Chemical structure

derivative of acrylic acid

Physical state

pale yellow solid at room temperature

Primary use

synthesis of pharmaceuticals and organic compounds
Commonly used as a building block for the production of other chemicals
Low toxicity
Generally regarded as safe for handling in controlled laboratory settings

Specific content

Used in research and development of new drugs and materials
Used in chemical manufacturing processes

Upstream product

• 371-40-4 4-fluoroaniline 
• 920-46-7 Methacryloyl chloride 
• 1353568-73-6 N-methyl-N-(4-fluorophenyl)methacrylamide 

Downstream Products

• 1588429-74-6 5-fluoro-1, 3-dimethyl-3-((phenylsulfonyl)methyl)indolin-2-one 
• 1414882-50-0 (2E,4Z)-n-butyl 6-p-fluorophenylamino-5-methyl-6-oxohexa-2,4-dienoate 
• 1414882-52-2 (2E,4Z)-n-butyl 6-(p-methoxylphenylamino)-5-methyl-6-oxohexa-2,4-dienoate 
• 1353568-73-6 N-methyl-N-(4-fluorophenyl)methacrylamide 
• 1256971-23-9 1-(4-fluorophenyl)-3-methyl-5,6-diphenylpyridin-2(1H)-one 

Relevant articles and documents

Bromo Radical-Mediated Photoredox Aldehyde Decarbonylation towards Transition-Metal-Free Hydroalkylation of Acrylamides at Room Temperature

Herein, we report a visible-light-mediated hydroalkylation reaction of alkenes using easily available aldehydes as alkyl sources via bromo radical-promoted photoredox decarbonylation. This protocol provides an alternative entry to C(sp3)?C(sp3) bond formation and features considerable advantages including mild and clean reaction conditions, obviation for transition-metal catalyst, and good functional group compatibility.

A benzene-bridged divanadium complex-early transition metal catalyst for alkene alkylarylation with PhI(O2CR)2viadecarboxylation

The synthesis, structure and catalytic activity of a benzene-bridged divanadium complex were comprehensively studied. The reduction of (Nacnac)VCl2(1) (Nacnac = (2,6-iPr2C6H3NCMe)2HC) supported by β-diketiminate with potassium graphite (KC8) by employing benzene as the solvent allows access to the benzene-bridged inverted-sandwich divanadium complex (μ-η6:η6-C6H6)[V(Nacnac)]2(2a), which can catalyze alkene alkylarylation with hypervalent iodine(iii) reagents (HIRs)viadecarboxylation to generate regioselectively diverse indolinones. Furthermore, the mild nature of this reaction was amenable to a wide range of functionalities on alkenes and HIRs. Mechanistic studies revealed a relay sequence of decarboxylative radical alkylation/radical arylation/oxidative re-aromatization.

Copper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant

An unprecedented N-demethylation of N-methyl amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.