30963-12-3

Basic information

• Product Name: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE
• Synonyms: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE;2-(1-Methylhydrazino)-3-nitropyridine;N-METHYL-N-(3-NITROPYRIDIN-2-YL)HYDRAZINE;1-Methyl-1-(3-nitro-2-pyridinyl)hydrazine;1-Methyl-1-(3-nitropyridin-2-yl)hydrazine
• CAS NO: 30963-12-3
• Molecular Formula: C₆H₈N₄O₂
• Molecular Weight: 168.15
• Mol File: 30963-12-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 319°C at 760 mmHg
• Flash Point: 146.7°C
• Appearance: /
• Density: 1.405g/cm³
• Vapor Pressure: 0.000348mmHg at 25°C
• Refractive Index: 1.658
• PKA: 2.55±0.10(Predicted)
• CAS DataBase Reference: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE(30963-12-3)
• EPA Substance Registry System: 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE(30963-12-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 30963-12-3(Hazardous Substances Data)

Usage

General Description

1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE is a chemical compound with the molecular formula C7H9N5O2. It is an organic compound containing a nitro group and a pyridine ring. It is a hydrazine derivative and is primarily used as a building block and intermediate in organic synthesis. 1-METHYL-1-(3-NITRO-2-PYRIDYL)HYDRAZINE is also known for its potential use in the pharmaceutical industry due to its biological activity, particularly its potential as an antitumor agent. However, it is important to handle this chemical with care as it may have hazardous effects on human health and the environment.

InChI:InChI=1/C6H8N4O2/c1-9(7)6-5(10(11)12)3-2-4-8-6/h2-4H,7H2,1H3

Upstream product

• 5470-18-8 2-Chloro-3-nitropyridine 
• 60-34-4 methylhydrazine 

Downstream Products

• 110606-69-4 ethyl 1,2,3,4-tetrahydro-1-methyl-3-phenylpyrido<3,2-e>-1,2,4-triazine-3-carboxylate 
• 110606-62-7 ethyl 2-phenylacetate 

Relevant articles and documents

Synthesis of Hydrazinylpyridines via Nucleophilic Aromatic Substitution and Further Transformation to Bicyclo[22.2]octenes Fused with Two N -Aminosuccinimide Moieties

Efficient and reliable synthesis of substituted hydrazinylpyridines in thick-wall ACE tubes via nucleophilic substitution of a chlorine substituent in different chloropyridines is presented. Hydrazine hydrate and alkylhydrazines were used as nucleophiles and simple alcohols and diethyl ether were the only organic solvents necessary, making the process environmentally and user friendly, potentially reaching 100% atomic efficiency. In the next step, transformations of succinic anhydride moieties fused to the bicyclo[2.2.2]octene framework into succinimide moieties via nucleophilic substitution of oxygens were conducted. As nucleophiles two of the synthesized hydrazinylpyridines (2-hydrazinyl-3-nitropyridine and 2-hydrazinyl-5-nitropyridine) and also hydrazine hydrate, phenylhydrazine, and 4-nitrophenylhydrazine were used. Reactions were again carried out in ACE tubes and only simple alcohols, diethyl ether, and acetone were needed as solvents. One of the prepared bicyclo[2.2.2]octene adducts displayed water solubility thus being a promising candidate for future studies as a novel bidentate ligand for various metal cations in aqueous solutions or acting as an unprecedented halogen bond acceptor.

Synthesis of pyrido[3,2-e]pyrrolo[2,1-c][1,2,4]triazines from pyrido[3,2-e][1,2,4]triazine derivatives

In carrying on our interest in heteropolycyclic structures with biological activities, we projected the preparation of compounds containing the pyrido[3,2-e][1,2,4]triazine or pyrido[2,3-b][1,4]triazepine systems. The established synthetic approach for the preparation of latter system led to the triazine derivatives 5a-f while a new bicyclic triazepine structure 6 is accomplished with difficulty. In expanding the pyridotriazine structure, we obtained derivatives of a new tricyclic structure, 5-substituted-6a-ethyloxycarbonyl-5,6,6a,7-tetrahydropyrido[2,3- e]pyrrolo[2,1-c][1,2,4]triazin-9(8H)-ones 8 in which the triazine ring is fused with a pyrrole nucleus. Compounds 5a-f and 8a,b will be tested as potential CNS depressant, antiinflammatory, analgesic and antibacterial agents.