309913-83-5

Basic information

• Product Name: talmapimod
• Synonyms: talmapimod;6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-1H-indole-3-acetamide;Unii-B1E00kq6nt;6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-Indole-3-acetamidehydrochloride;SCIO 469 hydrochloride;6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)Methyl]-2,5-diMethyl-1-piperazinyl]carbonyl]-N,N,1-triMethyl-α-oxo-1H-indole-3-acetaMide;SCIO 469;Scios 469
• CAS NO: 309913-83-5
• Molecular Formula: C₂₇H₃₀ClFN₄O₃
• Molecular Weight: 513.01
• Mol File: 309913-83-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 657.971 °C at 760 mmHg
• Flash Point: 351.729 °C
• Appearance: /
• Density: 1.29
• Storage Temp.: Desiccate at +4°C
• PKA: 6.52±0.70(Predicted)
• CAS DataBase Reference: talmapimod(CAS DataBase Reference)
• NIST Chemistry Reference: talmapimod(309913-83-5)
• EPA Substance Registry System: talmapimod(309913-83-5)

Safety Data

• Hazardous Substances Data: 309913-83-5(Hazardous Substances Data)

Usage

Description

Talmapimod is an indolecarboxamide that acts as a potent inhibitor of mitogen-activated protein kinase (MAPK). It is obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group of (2S,5R)-1-[(4-fluorophenyl)methyl]-2,5-dimethylpiperazine. Talmapimod exhibits anti-cancer properties and has been shown to reduce human myeloma cell growth in vivo.

Uses

Used in Cancer Therapy:
Talmapimod is used as an anti-cancer agent for reducing human myeloma cell growth in vivo during both early and advanced phases of the disease in mouse xenograft models.
Used in Rheumatoid Arthritis Treatment:
Talmapimod is used as an inhibitor of tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 synthesis in patients with active rheumatoid arthritis (RA), helping to manage the symptoms and progression of the disease.

Upstream product

• 124-40-3 dimethyl amine 

Relevant articles and documents

PHARMACEUTICAL FORMULATIONS OF AN INDOLE-TYPE DERIVATIVE AND RELATED METHODS OF USE

The invention is directed to pharmaceutical compositions comprising the compound and methods of use of said compositions for the treatment of conditions mediated by p38 MAP kinase. The invention provides formulations and dosage schedules, and it also prov