309967-53-1

Basic information

• Product Name: 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-6-N-benzoyladenosine
• Synonyms: 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-6-N-benzoyladenosine
• CAS NO: 309967-53-1
• Molecular Weight: 629.634
• Mol File: 309967-53-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-6-N-benzoyladenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-6-N-benzoyladenosine(309967-53-1)
• EPA Substance Registry System: 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-6-N-benzoyladenosine(309967-53-1)

Safety Data

• Hazardous Substances Data: 309967-53-1(Hazardous Substances Data)

Upstream product

• 148692-01-7 N⁶-benzoyl-3’,5’-O-di-tert-butylsilyl adenosine 
• 4546-55-8 N-benzoyladenosine 
• 160284-17-3 bis(2-cyano-1,1-dimethylethyl) N,N-diethylphosphoramidite 

Downstream Products

• 309967-57-5 2'-O-[bis(2-cyano-1,1-dimethylethoxy)thiophosphoryl]-5'-O-(4,4'-dimethoxytrityl)-6-N-benzoyladenosine 

Relevant articles and documents

New strategies for the chemical synthesis of biologically important nucleic acid derivatives

This paper describes general methods for the synthesis of N- phosphorylated ribonucleosides and oligonucleotides containing a 2'-O- phosphorylated or 2'-O-thiophosphorylated ribonucleoside. The NMR-based conformational analysis and computational molecular dynamics simulation of the 2'-O-phosphorylated ribonucleoside residue in such modified oligonucleotides suggested that the ribose residue existed preferentially in a C2'-endo conformation. It was also found that simple heating of 2'-O- phosphorylated oligonucleotides resulted in rapid dethiophosphorylation.