3106-11-4

Basic information

• Product Name: N-[2-oxo-2-(phenylamino)ethyl]benzamide
• Synonyms: benzamide, N-[2-oxo-2-(phenylamino)ethyl]-; N-(2-Anilino-2-oxoethyl)benzamide
• CAS NO: 3106-11-4
• Molecular Formula: C₁₅H₁₄N₂O₂
• Molecular Weight: 254.2839
• Mol File: 3106-11-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 563.6°C at 760 mmHg
• Flash Point: 232.7°C
• Density: 1.226g/cm³
• Vapor Pressure: 1E-12mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: N-[2-oxo-2-(phenylamino)ethyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-oxo-2-(phenylamino)ethyl]benzamide(3106-11-4)
• EPA Substance Registry System: N-[2-oxo-2-(phenylamino)ethyl]benzamide(3106-11-4)

Safety Data

• Hazardous Substances Data: 3106-11-4(Hazardous Substances Data)

Upstream product

• 495-69-2 Hippuric Acid 
• 118-92-3 anthranilic acid 
• 53587-10-3 hippuryl chloride 
• 62-53-3 aniline 
• 57461-31-1 hippuroyl azide 
• 1199-01-5 2-phenylazlactone 
• 98-88-4 benzoyl chloride 
• 1205-08-9 methyl hippurate 
• 2979-64-8 hippuroylmercapto-acetic acid 
• 7732-18-5 water 
• 1499-53-2 ethyl hippurate 
• 103-72-0 phenyl isothiocyanate 
• 14371-10-9 (E)-3-phenylpropenal 
• 555-48-6 2-amino-N-phenyl-acetamide 

Downstream Products

• 861339-06-2 5-chloro-1,2-diphenyl-1H-imidazole 
• 51254-00-3 4-( N,N-dimethylaminomethylene)-2-phenyl-2-oxazolin-5-one 

Relevant articles and documents

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Synthesis and anticonvulsant activity of some N-(benzoyl)glycinanilide derivatives

Glycine is a major inhibitory neurotransmitter and recent studies have shown that certain lipophilic glycine derivatives demonstrate anticonvulsant activity in animal epilepsy models. On the other hand, anilide is another fruitful structure for designing potential anticonvulsant agents. Ameltolide, ralitoline and some phthalimide derivatives are the examples of anilide analogs with potent anticonvulsant activity. In this study, two key structural pharmacophores were combined and a series of N-benzoylglycinanilide derivatives were designed. Their anticonvulsant activities evaluated against maximal electroshock (MES) and subcutaneous metrazole seizure tests, whereas their neurotoxicity was examined by rotarod test. The preliminary screening results indicated that majority of the compounds were effective in the MES test. None of the compounds showed neurotoxicity according to the rotarod test at studied doses. The most active compound in the series is N-(2-((4-methoxyphenyl)amino)- 2-oxoethyl)benzamide (compound 8) which bearing 4-methoxy substituent on the N-phenyl ring.

TFFH as a useful reagent for the conversion of carboxylic acids to anilides, hydrazides and azides

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