31118-87-3

Basic information

• Product Name: 1-(2,4,6-TRICHLOROPHENYL)-2-THIOUREA
• Synonyms: N-(2,4,6-TRICHLOROPHENYL)THIOUREA;2,4,6-TRICHLOROPHENYLTHIOUREA;1-(2,4,6-TRICHLOROPHENYL)-2-THIOUREA;1-(2,4,6-Trichlorophenyl)thiourea
• CAS NO: 31118-87-3
• Molecular Formula: C₇H₅Cl₃N₂S
• Molecular Weight: 255.55
• Product Categories: Organic Building Blocks;Sulfur Compounds;Thioureas
• Mol File: 31118-87-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 206-211 °C(lit.)
• Boiling Point: 342.7 °C at 760 mmHg
• Flash Point: 161.1 °C
• Appearance: /
• Density: 1.665 g/cm³
• Vapor Pressure: 7.37E-05mmHg at 25°C
• Refractive Index: 1.732
• CAS DataBase Reference: 1-(2,4,6-TRICHLOROPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4,6-TRICHLOROPHENYL)-2-THIOUREA(31118-87-3)
• EPA Substance Registry System: 1-(2,4,6-TRICHLOROPHENYL)-2-THIOUREA(31118-87-3)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 31118-87-3(Hazardous Substances Data)

Usage

General Description

1-(2,4,6-TRICHLOROPHENYL)-2-THIOUREA, also known as triclocarban, is a chemical compound that is commonly used as an antimicrobial agent in personal care products such as soaps, detergents, and body washes. It is a white, crystalline solid that is often added to these products to inhibit the growth of bacteria and fungi. Triclocarban has been the subject of concern due to its potential impact on the environment and human health. Studies have shown that it can persist in the environment and has been detected in water sources. There is also evidence to suggest that triclocarban may disrupt hormone function and have negative effects on aquatic life. As a result, there has been a push to regulate and reduce the use of triclocarban in consumer products.

InChI:InChI=1/C7H5Cl3N2S/c8-3-1-4(9)6(5(10)2-3)12-7(11)13/h1-2H,(H3,11,12,13)

Upstream product

• 540-72-7 sodium thiocyanide 
• 634-93-5 2,4,6-trichloroaniline 
• 45943-14-4 benzoyl isothiocyanate 

Downstream Products

• 916043-87-3 (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,4,6-trichlorophenyl)amino]-1,3-thiazol-4(5H)-one 
• 916043-89-5 2-[(2,4,6-trichlorophenyl)amino]-1,3-thiazol-4(5H)-one 
• 123414-52-8 N-[(3aR,6aR)-5,5-Dioxo-3-(2,4,6-trichloro-phenyl)-hexahydro-5λ⁶-thieno[3,4-d]thiazol-(2Z)-ylidene]-acetamide 
• 123414-46-0 (3aR,6aR)-5,5-Dioxo-3-(2,4,6-trichloro-phenyl)-hexahydro-5λ⁶-thieno[3,4-d]thiazol-2-ylideneamine; hydrobromide 

Relevant articles and documents

Discovery of aminothiazole derivatives as novel human enterovirus A71 capsid protein inhibitors

Enterovirus A71 (EV-A71), one of the major pathogens that causes hand, foot and mouth disease (HFMD), has seriously threatened the health and safety of young children. In this study, aminothiazole derivatives were synthesized and screened against EV-A71 in Rhabdomyosarcoma (RD) cells. The best compound (12s), with a biphenyl group, showed activity against EV-A71 (EC50: 0.27 μM) but also against a series of different human enteroviruses without significant cytotoxicity (CC50 > 56.2 μM). Mechanistic studies including time-of-drug-addition assays, viral entry assays and microscale thermophoresis (MST) experiments, showed that 12s binds to EV-A71 capsid and blocks the binding between the viral protein VP1 and the relevant human scavenger receptor class B member 2 (hSCARB2).