31122-75-5

Basic information

• Product Name: 5-Acetamido-2,4,6-triiodoisophthaloyl Dichloride
• Synonyms: 5-Acetamido-2,4,6-triiodoisophthaloyl Dichloride;5-(AcetylaMino)-2,4,6-triiodo-1,3-benzenedicarbonyl Dichloride;5-AcetaMido-2,4,6-triiodo-isophthaloyl Chloride
• CAS NO: 31122-75-5
• Molecular Formula: C₁₀H₄Cl₂I₃NO₃
• Molecular Weight: 637.76307
• Product Categories: Aromatics;Intermediates
• Mol File: 31122-75-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 219-230 °C (decomp)
• Boiling Point: 617.8±55.0 °C(Predicted)
• Appearance: /
• Density: 2.640±0.06 g/cm3(Predicted)
• Solubility: Chloroform
• PKA: 11.81±0.70(Predicted)
• CAS DataBase Reference: 5-Acetamido-2,4,6-triiodoisophthaloyl Dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Acetamido-2,4,6-triiodoisophthaloyl Dichloride(31122-75-5)
• EPA Substance Registry System: 5-Acetamido-2,4,6-triiodoisophthaloyl Dichloride(31122-75-5)

Safety Data

• Hazardous Substances Data: 31122-75-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Intermediate in the production of Ioxitalamic Acid

Upstream product

• 75-36-5 acetyl chloride 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 1187316-80-8 {2-[3-acetylamino-5-(2-tert-butoxycarbonylaminoethylcarbamoyl)-2,4,6-triiodobenzoylamino]ethyl}carbamic acid tert-butyl ester 
• 31127-80-7 N,N'-bis(2,3-dihydroxypropyl)-5-acetamido-2,4,6-triiodoisophthalamide 
• 152401-32-6 5-acetamido-N,N'dimethyl-N,N'-bis[2,2-bis(hydroxymethyl)-3-hydroxypropyl]-2,4,6-triiodoisophthalamide 
• 554-68-7 triethylamine hydrochloride 

Relevant articles and documents

Novel triiodinated compounds, preparation method thereof and X-ray contrast comprising the same

The present invention relates to a novel tri-iodinated compound, a manufacturing method for the novel tri-iodinated compound, and an X-ray contrast agent comprising the same and, more specifically, to a compound represented by Chemical Formula 1, a manufa

DETERMINATION OF KIDNEY FUNCTION

The present invention provides an isotopically labelled marker of formula (I): where R1 -R5 are as defined herein; characterised in that one or more of the H, N, C or O atoms in the compound of formula (I) is replaced with one or more of2H, 13C, 15N, 17O or 18O respectively, methods for using the inventive marker in detecting the presence or absence of a filtration marker in a sample, measuring the rate of glomerular filtration in a subject and/or diagnosing kidney disease and/or damage in a subject.

A PROCESS FOR THE PREPARATION OF 5- ACETYL (2,3-DIHYDROXYPROPYL)AMINO]-N,N'-BIS (2,3-DIHYDROXYPROPYL)-2,4,6- TRIIODO-1,3-BENZENEDICARBOXAMIDE

A process for the preparation of 5-[acetyl(2,3-dihydroxypropyl)amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide of formula (I), starting from 5-amino-1,3-benzenedicarboxylic acid of formula (II), comprising the following steps: step a) is the reaction in heterogeneous phase between 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylic acid and thionyl chloride in a solvent selected from the group consisting of: straight or branched (C7-C16) hydrocarbons, (C7-C8) aromatic hydrocarbons, 1,1,1-trichloroethane, n-butyl acetate, diglyme (diethylene glycol dimethyl ether), in the presence of catalytic amounts of a tertiary amine, to give compound (III); step b) is the acetylation reaction of compound (III) with glacial acetic acid both as the solvent and the reagent and thionyl chloride; step c) is the formation of compound (V) by reaction of the compound (IV) with 1-amino-2,3-propanediol, by reaction of compound (IV) in a dipolar aprotic solvent, selected from the group of dimethylformamide (DMF), dimethylacetamide (DMA), dimethylsulfoxide (DMSO) or N-methyl-pyrrolidinone; step d) is the alkylation of the compound (V) in aqueous solution at basic pH, by addition of a sodium hydroxide-calcium hydroxide mixture, with 3-chloro-1,2-propanediol or epichlorohydrin, at a temperature of 40-90 DEG C.