31181-90-5

Basic information

• Product Name: 5-Bromopyridine-2-carbaldehyde
• Synonyms: 5-BROMO-2-PYRIDINECARBALDEHYDE;5-BROMO-2-PYRIDINECARBOXALDEHYDE;5-BROMO-2-FORMYLPYRIDINE;5-BROMOPICOLINALDEHYDE;5-BROMO-PYRIDINE-2-CARBALDEHYDE;5-BROMOPYRIDINE-2-CARBOXALDEHYDE;2-Formyl-5-Bromopyridine;5-Bromopyridine-2-carboxaldehyde 95%
• CAS NO: 31181-90-5
• Molecular Formula: C₆H₄BrNO
• Molecular Weight: 186.01
• EINECS: -0
• Product Categories: Aldehydes;blocks;Bromides;Pyridines;Pyridine;Carbonyl Compounds;Heterocycles;pharmacetical;Aldehyde;Building Blocks;Pyridine Series
• Mol File: 31181-90-5.mol
• Article Data: 56

Chemical Properties

• Melting Point: 93 °C
• Boiling Point: 70°C/26mmHg(lit.)
• Flash Point: 97.562 °C
• Appearance: /
• Density: 1.683 g/cm³
• Vapor Pressure: 0.044mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 2-8°C
• PKA: 1.36±0.10(Predicted)
• Water Solubility: Insoluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 5-Bromopyridine-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromopyridine-2-carbaldehyde(31181-90-5)
• EPA Substance Registry System: 5-Bromopyridine-2-carbaldehyde(31181-90-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 22-26-36/37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 31181-90-5(Hazardous Substances Data)

Usage

Description

5-Bromopyridine-2-carbaldehyde is an organic compound that serves as an important intermediate in the synthesis of various organic chemicals. It is characterized by its light yellow crystalline appearance and is known for its reactivity in chemical reactions, making it a valuable component in the development of new compounds and materials.

Uses

Used in Organic Chemical Synthesis:
5-Bromopyridine-2-carbaldehyde is used as an organic chemical synthesis intermediate for the production of a wide range of compounds. Its unique structure and reactivity allow it to be a key component in the creation of various pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Bromopyridine-2-carbaldehyde is used as a building block for the development of new drugs. Its ability to participate in various chemical reactions enables the synthesis of diverse drug candidates with potential therapeutic applications.
Used in Agrochemical Industry:
5-Bromopyridine-2-carbaldehyde also finds application in the agrochemical industry, where it is utilized as a starting material for the synthesis of pesticides, herbicides, and other crop protection agents. Its versatility in chemical reactions allows for the development of innovative and effective products to protect crops from pests and diseases.
Used in Research and Development:
In the field of research and development, 5-Bromopyridine-2-carbaldehyde is employed as a valuable compound for exploring new chemical reactions and understanding the underlying mechanisms. Its unique properties make it an attractive candidate for studying various aspects of organic chemistry and contributing to the advancement of scientific knowledge.
Used in Material Science:
5-Bromopyridine-2-carbaldehyde can also be used in the field of material science, where it may contribute to the development of new materials with specific properties. Its reactivity and structural features can be exploited to create novel materials with applications in various industries, such as electronics, coatings, and adhesives.

InChI:InChI=1/C6H4BrNO/c7-5-1-2-6(4-9)8-3-5/h1-4H

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 29682-15-3 methyl 5-bromopicolinate 
• 3430-13-5 5-bromo-2-methylpyridine 
• 94-36-0 dibenzoyl peroxide 
• 4985-92-6 5-methylpicolinaldehyde 
• 1121-60-4 pyridine-2-carbaldehyde 
• 97483-77-7 2-Cyano-5-bromopyridine 
• 223463-13-6 2-iodo-5-bromopyridine 
• 31181-64-3 5-bromo-2-methyl-pyridine-N-oxide 
• 31181-74-5 (5-bromopyridin-2-yl)methyl acetate 
• 364794-27-4 5-bromo-2-dibromomethyl-pyridine 
• 88139-91-7 (5-bromopyridin-2-yl)methanol 

Downstream Products

• 364794-78-5 5-bromo-2-(1-piperidinylmethyl)pyridine 
• 192642-82-3 6-bromo-[1,2,3]triazolo[1,5-a]pyridine 
• 1144100-63-9 C₁₅H₉NO₂ 
• 917397-92-3 1-(5-bromo-pyridin-2-yl)-2,2,2-trifluoroethanol 
• 1384182-26-6 5-bromo-2-pyridyl-N-(2'-methylthiophenyl)methyleneimine 
• 586-98-1 2-Hydroxymethylpyridine 
• 1446819-49-3 tert-butyl 4-[[5-(3-fluorophenyl)pyridin-2-yl]methyl]piperazine-1-carboxylate 
• 1446819-50-6 1-[[5-(3-fluorophenyl)pyridin-2-yl]methyl]piperazine 
• 294848-51-4 1-[3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl]-3-{4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl} urea 
• 884495-16-3 5-bromo-2-(1,3-dioxolane-2-yl)pyridine 
• 88139-91-7 (5-bromopyridin-2-yl)methanol 
• 905290-12-2 (5-bromo-pyridin-2-ylmethyl)-(3,4,5-trimethoxy-phenyl)-amine 
• 192642-97-0 (E,Z)-N’-((5-bromopyridin-2-yl)methylene)-4-methylbenzene-sulfonohydrazide 
• 1245735-33-4 methyl 2-benzoyl-5-(5-((4-chlorophenyl)(methyl)amino)pyridine-2-carbonyl)benzoate 

Relevant articles and documents

Simultaneous Generation of a [2 × 2] Grid-Like Complex and a Linear Double Helicate: a Three-Level Self-Sorting Process

Two constitutional dynamic libraries (CDLs) - each containing two amines, two dialdehydes, and two metal salts - have been found to self-sort, generating two pairs of imine-based metallosupramolecular architectures (sharing no component) each with a [2 ×

Modeling the syn disposition of nitrogen donors in non-heme diiron enzymes. Synthesis, characterization, and hydrogen peroxide reactivity of diiron(III) complexes with the syn N-donor ligand H2BPG2DEV

In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiron enzymes, we prepared a new dinucleating ligand, H2BPG2DEv, that provides this geometric feature. The ligand incorporates biologically

Enhancement of 4-electron O2 reduction by a Cu(II)-pyridylamine complex via protonation of a pendant pyridine in the second coordination sphere in water

We have synthesised a novel copper(II) complex with a pyridine pendant as a proton relay port for electrocatalytic 4e- reduction of O2 in water. The enhancement of the electrocatalytic O2 reduction via protonation of the pyridine pendant is demonstrated in comparison with a copper(II) complex without the pyridine pendant.

SUBSTITUTED 1,5-NAPHTHYRIDINES OR QUINOLINES AS ALK5 INHIBITORS

The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.

A 2 - bromo -4 - pyridylaldehyde preparation method (by machine translation)

The invention belongs to the field of organic synthesis, in particular relates to a 2 - bromo - 4 - pyridylaldehyde preparation method, comprises the following steps: (1) 2 - bromo - 4 - methyl pyridine preparation: will be hydrobromic arranged in four bottle, added under mixing 2 - amino - 4 - methylpyridine, to be 2 - amino - 4 - methyl pyridine completely after dissolving, cooling to - 20 °C, slow [...], dropping process control temperature is - 20 °C - - 15 °C; dropped stirring for 90 - 120 min, then dropping sodium nitrite solution, after adding, the temperature to 20 °C, stirring 45 - 60 min and then cooling to - 20 °C - - 25 °C, sodium hydroxide solution, dropping process control temperature is lower than - 15 °C - - 10 °C; after adding, the temperature is raised to 20 °C and stirring 1 h, extraction, the combined organic phase, washing, drying, concentration; (2) 2 - bromo - 4 - pyridylaldehyde preparation. The beneficial effect of the invention is: mild reaction conditions, is easy to operate, after treatment is simple, and easy to enlarge production, is extremely suitable for industrial production; high yield, low prices of raw materials, the production cost is low. (by machine translation)