312312-75-7

Basic information

• Product Name: Ethyl 2-oxo-3-phenylcyclopentanecarboxylate
• Synonyms: Ethyl 2-oxo-3-phenylcyclopentanecarboxylate;Cyclopentanecarboxylic acid,2-oxo-3-phenyl-,ethyl ester
• CAS NO: 312312-75-7
• Molecular Formula: C₁₄H₁₆O₃
• Molecular Weight: 232.277
• Mol File: 312312-75-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 351.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.141±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.53±0.40(Predicted)
• CAS DataBase Reference: Ethyl 2-oxo-3-phenylcyclopentanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-oxo-3-phenylcyclopentanecarboxylate(312312-75-7)
• EPA Substance Registry System: Ethyl 2-oxo-3-phenylcyclopentanecarboxylate(312312-75-7)

Safety Data

• Hazardous Substances Data: 312312-75-7(Hazardous Substances Data)

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 4553-07-5 ethyl phenylcyanoacetate 
• 140-29-4 phenylacetonitrile 
• 1924-30-7 diethyl 2-phenylhexanedioate 
• 1198-34-1 2-Phenylcyclopentanone 
• 623-49-4 ethyl cyanoformate 
• 100-58-3 phenylmagnesium bromide 
• 120-92-3 cyclopentanone 

Downstream Products

• 1263868-42-3 2-chloro-N-(5-isopropyl-2-methylphenyl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263868-34-3 2-chloro-4-(3-chloroazetidin-1-yl)-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine 
• 1263868-33-2 2-chloro-N-isopropyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263868-32-1 2-chloro-N-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263868-31-0 2-chloro-N-cyclopropyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263868-29-6 2-chloro-N-trideuteromethyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263868-28-5 4-(azetidin-1-yl)-2-chloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine 
• 1263868-27-4 2-chloro-N-ethyl-N-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263868-26-3 2-chloro-N,N-dimethyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263868-25-2 2-chloro-N-methyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine 
• 1263868-24-1 2,4-dichloro-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine 
• 1263865-06-0 N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-isopropyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-05-9 N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclobutyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 
• 1263865-04-8 N₂-(4-(4-chloro-1H-imidazol-1-yl)-3-methoxyphenyl)-N₄-cyclopropyl-7-phenyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine 

Relevant articles and documents

Dynamic Kinetic Resolution of I-Substituted Cyclic β-Ketoesters via Asymmetric Hydrogenation: Constructing Chiral Cyclic β-Hydroxyesters with Three Contiguous Stereocenters

An efficient asymmetric hydrogenation of racemic I-substituted cyclic β-ketoesters via dynamic kinetic resolution to provide chiral cyclic β-hydroxy esters with three contiguous stereocenters is reported. Using a chiral spiro iridium catalyst (R)-5 (Ir-SpiroSAP), a series of racemic I-Aryl/alkyl substituted cyclic β-ketoesters were hydrogenated to the corresponding chiral cyclic β-hydroxy esters in high yields (84-97%) with good to excellent enantioselectivities (69->99% ee) and cis,cis-selectivities (up to >99:1).

COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION

The present disclosure provides a series of compounds of the formula (I), which modulate β-amyloid peptide (β-ΑΡ) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-ΑΡ) production.

Synthesis of annelated analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442) using 1,3-oxazine-2,4(3H)-diones as key intermediates

Condensation of ethyl 3-phenyl-2-oxocyclopentanecarboxylate 5 with 2-(S-methylthio)isourea followed by hydrolysis with HC1 gave 6,7-dihydro-7-phenylcyclopenta[e][1,3]oxazine-2,4(3H,5H)-dione (10a). 7,8-Dihydro-8-phenyl-6H-cyclohexa[e][1,3]oxazine-2,4(3H,5H)-dione (10b) was synthesised by reacting 2-phenylcyclohexanone (9b) with N-(chlorocarbonyl) isocyanate. The oxazines 10a,b were reacted with ammonia to obtain the corresponding uracil derivatives 12a,b which after silylation were alkylated with diethoxymethane using trimethylsilyl triflate (TMS-triflate) as the catalyst or alkylated with chloromethyl ethyl ether to give annelated MKC-442 analogues 2,3 which are locked in a conformation close to the one of MKC-442. In spite of this, only moderate activities were found against HIV-1 for the annelated analogues of MKC-442. The Royal Society of Chemistry 2000.