312693-72-4 Usage
Description
2'-Deoxyguanosine is a purine nucleoside with diverse biological activities. It is a white to off-white solid that is soluble in NH4OH 1 M. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite, and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside, and it is functionally related to guanosine.
Uses
Used in Biomedical Research:
2'-Deoxyguanosine is used as a nucleoside supplement for various applications in biomedical research. It is used to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish, to support deoxyribonucleotide triphosphate (dNTP) synthesis in tissue culture medium, and to eliminate endogenous thymocytes in RPMI (Roswell Park Memorial Institute)-1640 medium.
Used in Stromal Cell Purification:
2'-Deoxyguanosine monohydrate has been used in stromal cell purification, which is an important process in cell biology and regenerative medicine.
Used for Quantification of Whole Cell dNTP:
2'-Deoxyguanosine has also been used for the quantification of whole cell deoxyribonucleotide triphosphate (dNTP), which is crucial for understanding cellular processes and developing new therapeutic strategies.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2'-Deoxyguanosine is used as an active pharmaceutical ingredient for the development of drugs targeting various diseases, including cancer and other genetic disorders.
Used in Biochemical Analysis:
2'-Deoxyguanosine is used as a biochemical reagent for the analysis of nucleic acids and enzymes involved in DNA synthesis and repair, providing valuable insights into the molecular mechanisms of these processes.
Biochem/physiol Actions
Deoxyguanosine (dG) is a purine nucleoside that upon sequential phosphorylation (kinases) forms deoxyguanosine triphosphate (dGTP) which is used by DNA polymerases and reverse transcriptases to synthesize DNA(s). Deoxyguanosine is the most electron-rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.
Check Digit Verification of cas no
The CAS Registry Mumber 312693-72-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,2,6,9 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 312693-72:
(8*3)+(7*1)+(6*2)+(5*6)+(4*9)+(3*3)+(2*7)+(1*2)=134
134 % 10 = 4
So 312693-72-4 is a valid CAS Registry Number.
