312753-75-6Relevant articles and documents
Scalable ruthenium-catalyzed asymmetric synthesis of a key intermediate for the β2-adrenergic receptor agonist
Komiyama, Masato,Itoh, Takahiro,Takeyasu, Takumi
, p. 315 - 319 (2015)
An enantioselective and robust synthetic process to obtain a useful intermediate for the β2-adrenergic receptor agonist is described. Asymmetric transfer hydrogenation of ketone 1c by (S,S)-3b (Ms-DENEB) afforded chiral alcohol 2c in 71% isolated yield and 99% ee. The deprotection completed the synthesis of (R)-5 in 41% overall yield from 1b, which is readily commercially available.
Beta2-adrenoceptor agonists
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Page/Page column 17, (2008/06/13)
Compounds of formula in free or salt or solvate form, where Ar is a group of formula Y is carbon or nitrogen and R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n, p, q and r are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of obstructive or inflammatory airways diseases.