312924-69-9

Basic information

• Product Name: Propanamide, 2-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-
• CAS NO: 312924-69-9
• Molecular Formula: C16H24N2O
• Molecular Weight: 260.379
• Mol File: 312924-69-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Propanamide, 2-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-(312924-69-9)
• EPA Substance Registry System: Propanamide, 2-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-(312924-69-9)

Safety Data

• Hazardous Substances Data: 312924-69-9(Hazardous Substances Data)

Upstream product

• 949-69-9 N-benzyl-4-(N-hydroxyimino)piperidine 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 79-31-2 isobutyric Acid 
• 97-72-3 2-Methylpropionic anhydride 
• 79-30-1 isobutyryl chloride 

Downstream Products

• 1033304-07-2 C₁₉H₂₈N₄ 
• 795310-37-1 4-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)piperidine 
• 1374567-31-3 C₂₆H₃₀ClN₅O₃ 
• 941706-63-4 1-Benzyl-4-(5-isopropyl-1H-tetrazol-1-yl)piperidine 
• 795310-77-9 1-benzyl-4-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)piperidine 

Relevant articles and documents

1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided are 1-(3-aminopropyl) substituted cyclic amine compounds as represented by formula (I), pharmaceutically acceptable salts, enantiomers, diastereoisomers, racemates and mixtures thereof, and a method of synthesizing said 1-(3-aminopropyl) substituted cyclic amine compounds by using aromatic heterocyclic formaldehyde as raw material. Said compounds can be used as CCR 5 antagonist for the treatment of HIV infection.

Efficient synthesis and identification of novel propane-1,3-diamino bridged CCR5 antagonists with variation on the basic center carrier

By employing pharmacophore-based design and the privileged fragments reassembly, a series of piperidine-/tropane-/piperazine-bridged CCR5 antagonists were designed and synthesized via an efficient convergent synthesis strategy, with focus on the optimal choice of the basic center carrier structure. Significantly, the 4-amino-4-methylpiperidine bridged 1-acyl-1,3-propanediamine compounds were identified as a new class of nanomolar CCR5 antagonists, providing an efficient approach and novel scaffolds for further development of potent CCR5 inhibitors.

CHEMICAL COMPOUNDS

The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, Het and m are as defined in the description. The compounds of the present invention are modulators, especially antagonists, of the