312936-83-7

Basic information

• Product Name: 4-(1-[(4-bromophenyl)methyl]imidazol-5-ylmethyl)-1-(3-chlorophenyl)piperazin-2-one
• Synonyms: 4-(1-[(4-bromophenyl)methyl]imidazol-5-ylmethyl)-1-(3-chlorophenyl)piperazin-2-one
• CAS NO: 312936-83-7
• Molecular Weight: 459.773
• Mol File: 312936-83-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(1-[(4-bromophenyl)methyl]imidazol-5-ylmethyl)-1-(3-chlorophenyl)piperazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-[(4-bromophenyl)methyl]imidazol-5-ylmethyl)-1-(3-chlorophenyl)piperazin-2-one(312936-83-7)
• EPA Substance Registry System: 4-(1-[(4-bromophenyl)methyl]imidazol-5-ylmethyl)-1-(3-chlorophenyl)piperazin-2-one(312936-83-7)

Safety Data

• Hazardous Substances Data: 312936-83-7(Hazardous Substances Data)

Upstream product

• 220364-22-7 1-(4-Bromobenzyl)-5-hydroxymethyl-1H-imidazole 
• 238765-02-1 3-(4-bromo-benzyl)-3H-imidazole-4-carbaldehyde 
• 26177-44-6 4-bromobenzylamine hydrochloride 
• 183500-70-1 1-(3-chlorophenyl)-2-piperazinone 
• 742045-40-5 1-(4-bromobenzyl)-5-(chloromethyl)-1H-imidazole 

Downstream Products

• 1169394-30-2 4-[(5-[4-(3-chlorophenyl)-3-oxopiperazinyl]methylimidazol-1-yl)methyl]benzenecarbo-⁽¹⁴⁾C-nitrile hydrochloride 

Relevant articles and documents

Synthesis of a14C-labeled FPTase inhibitor via a Pd-catalyzed cyanation with Zn(14CN)2 and via bromo[ 14C]acetic acid

14C-Labeled farnesyl-protein transferase inhibitor 1a was required for drug metabolism studies. The first approach was to synthesize 14C-labeled 1b using Zn(14CN)2 in a Pd-catalyzed cyanation. A second approach was to prepare labeled 1c with the 14C-label in the piperazine ring. All metabolites from 1b were non-radioactive whereas the same metabolites from 1c were all radioactive and quantifiable. Copyright