312937-07-8

Basic information

• Product Name: 1-(3-chloro-phenyl)-4-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-piperazin-2-one
• CAS NO: 312937-07-8
• Molecular Weight: 547.099
• Mol File: 312937-07-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-chloro-phenyl)-4-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-piperazin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloro-phenyl)-4-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-piperazin-2-one(312937-07-8)
• EPA Substance Registry System: 1-(3-chloro-phenyl)-4-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-piperazin-2-one(312937-07-8)

Safety Data

• Hazardous Substances Data: 312937-07-8(Hazardous Substances Data)

Upstream product

• 51-45-6 histamine 
• 2564-05-8 2-chloro-N-(3-chlorophenyl)acetamide 
• 312937-01-2 2,2,2-trifluoro-N-(2-(1-trityl-1H-imidazol-4-yl)ethyl)acetamide 
• 195053-92-0 1-(Triphenylmethyl)-4-(2-amino-1-ethyl)imidazole 
• 50580-77-3 2,2,2-trifluoro-N-[2-(1H-imidazol-4-yl)ethyl]acetamide 
• 23147-58-2 glycolaldehyde dimer 
• 312937-03-4 N-(3-chloro-phenyl)-2-[2-(1-trityl-1H-imidazol-4-yl)-ethylamino]-acetamide 

Relevant articles and documents

Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I

Compound 1 has been shown to be a dual prenylation inhibitor with FPTase (IC50=2 nM) and GGPTase-I (IC50=95 nM). Analogues of 1, which replaced the cyanophenyl group with various biaryls, led to the discovery of highly potent dual FPTase/GGPTase-I inhibitors. 4-Trifluoromethylphenyl, trifluoropentynyl, and trifluoropentyl were identified as good p-cyano replacements.