313339-92-3

Basic information

• Product Name: 3,5-Dichloropyrazine-2-carbonitrile
• Synonyms: 3,5-Dichloropyrazine-2-carbonitrile;5-dichloropyrazine-2-carbonitrile;3,5-Dichloro-2-pyrazinecarbonitrile;3,5-Dichloropyrazinecarbonitrile;2-Cyano-3,5-dichloropyrazine, 2-Cyano-3,5-dichloro-1,4-diazine
• CAS NO: 313339-92-3
• Molecular Formula: C₅HCl₂N₃
• Molecular Weight: 173.99
• Mol File: 313339-92-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 277℃
• Flash Point: 121℃
• Appearance: /
• Density: 1.60
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -8.85±0.10(Predicted)
• CAS DataBase Reference: 3,5-Dichloropyrazine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloropyrazine-2-carbonitrile(313339-92-3)
• EPA Substance Registry System: 3,5-Dichloropyrazine-2-carbonitrile(313339-92-3)

Safety Data

• Hazardous Substances Data: 313339-92-3(Hazardous Substances Data)

Usage

General Description

3,5-Dichloropyrazine-2-carbonitrile is a chemical compound with the molecular formula C5HCl2N3. It is a pyrazine derivative with two chlorine atoms and a cyano group attached to the carbon atom at position 2. 3,5-Dichloropyrazine-2-carbonitrile is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized in the production of insecticides, herbicides, and fungicides. 3,5-Dichloropyrazine-2-carbonitrile is a highly reactive and toxic compound that must be handled with care and proper safety precautions. Its chemical properties and applications make it a valuable component in various industrial processes.

InChI:InChI=1/C5HCl2N3/c6-4-2-9-3(1-8)5(7)10-4/h2H

Upstream product

• 1207852-78-5 (E)-1-(3,5-dichloropyrazin-2-yl)-N-hydroxymethanimine 
• 312736-50-8 3,5-dichloropyrazine-2-carboxamide 

Downstream Products

• 1438419-82-9 (R)-5-((1-aminocyclopropyl)(cyclopropyl)methylamino)-3-(3-(pyrimidin-2-yl)phenylamino)pyrazine-2-carboxamide 
• 1438424-48-6 (R)-benzyl-1-((5-carbamoyl-6-(3-(pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate 
• 1438424-45-3 (R)-benzyl-1-((5-cyano-6-(3 (pyrimidin-2-yl)phenylamino)pyrazin-2-ylamino)(cyclopropyl)methyl)cyclopropylcarbamate 
• 1438419-63-6 5-((1R,2S)-2-aminocyclohexylamino)-3-(3-morpholino-5-(1H-pyrazol-1-yl)phenylamino)pyrazine-2-carboxamide 

Relevant articles and documents

Synthesis method of 3,5-dichloro-6-ethylpyrazineformamide

The invention discloses a synthetic method of 3,5-dichloro-6-ethylpyrazine formamide, and relates to the technical field of intermediate for synthesizing gilteritinib. The method is technically characterized by comprising the following steps: heating 2,6-dichloropyrazine and formamide to 70-130 DEG C, and carrying out free radical oxidation reaction under the action of persulfate to obtain 3,5-dichloropyrazine formamide; carrying out heating reflux on 3,5-dichloropyrazine formamide for 3-6 h under the action of a dehydrating agent, and synthesizing 3,5-dichloropyrazine formonitrile through dehydration; carrying out a Grignard reactionon the 3,5-dichloropyrazine formonitrile in an organic solvent A under the action of a methylation reagent to prepare 3,5-dichloro-2-acetylpyrazine; under theaction of an acidic catalyst and a silicon-hydrogen reducing agent, reducing the 3,5-dichloro-2-acetyl pyrazine in an organic solvent B to obtain 3,5-dichloro-2-ethyl pyrazine; and heating the 3,5-dichloro-2-ethyl pyrazine and formamide to 50-120 DEG C, and carrying out free radical oxidation reaction under the action of persulfate to obtain the 3,5-dichloro-6-ethylpyrazine formamide. According to the invention, the operation method is simple, the reaction conditions of the synthesis process are mild, the cost is reduced, and meanwhile high economic benefits can be brought.

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Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof

The present invention relates to a novel imidazotriazinone or imidazopyrazinone derivatives, a tautomer thereof, a stereomer and a mixture thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating tankyrase-related diseases comprising the same as active components.COPYRIGHT KIPO 2016