313345-09-4Relevant articles and documents
Development of a scaleable process for the synthesis of the A2a agonist, UK-371,104
Challenger, Stephen,Dessi, Yann,Fox, Darrell E.,Hesmondhalgh, Lynsey C.,Pascal, Pierre,Pettman, Alan J.,Smith, Julian D.
, p. 575 - 583 (2013/01/03)
The development and utilization of a scaleable process for the manufacture of the A2a agonist UK-371,104 (1) is described. Key steps in the synthesis include (i) a palladium-catalyzed cyanation reaction to prepare the nitrile 10, (ii) a telescoped convers