313545-32-3

Basic information

• Product Name: 2-CHLORO-6-FLUOROPHENYLBORONIC ACID
• Synonyms: (2-CHLORO-6-FLUOROBENZENE)BORONIC ACID;2-CHLORO-6-FLUOROPHENYLBORONIC ACID;2-Chloro-6-fluorobenzeneboronic acid 97%;2-Chloro-6-fluorobenzeneboronicacid97%;2-Chloro-6-fluorobenzeneboronic acid, 97% (H53079);2-Borono-1-chloro-3-fluorobenzene;Boronic acid,B-(2-chloro-6-fluorophenyl)-;B-(2-Chloro-6-fluorophenyl)boronic acid
• CAS NO: 313545-32-3
• Molecular Formula: C6H5BClFO2
• Molecular Weight: 174.37
• Product Categories: blocks;BoronicAcids;FluoroCompounds;Aryl;Boronic Acids;Boronic Acids and Derivatives
• Mol File: 313545-32-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 131-135 °C(lit.)
• Boiling Point: 299.8 °C at 760 mmHg
• Flash Point: 135.1 °C
• Appearance: White/Crystalline Powder
• Density: 1.41
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 8.03±0.58(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-FLUOROPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-FLUOROPHENYLBORONIC ACID(313545-32-3)
• EPA Substance Registry System: 2-CHLORO-6-FLUOROPHENYLBORONIC ACID(313545-32-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 313545-32-3(Hazardous Substances Data)

Usage

Description

2-Chloro-6-fluorophenylboronic acid is an organic compound that consists of a phenyl ring with a chlorine atom at the 2nd position and a fluorine atom at the 6th position, attached to a boronic acid group. It is a versatile building block in organic synthesis and has unique chemical properties due to the presence of both electron-withdrawing chlorine and electron-donating fluorine atoms.

Uses

Used in Suzuki Reaction:
2-Chloro-6-fluorophenylboronic acid is used as a reactant in the Suzuki coupling reaction, a widely employed method for the formation of carbon-carbon bonds in organic synthesis. It serves as a nucleophile to form new bonds with electrophilic partners, enabling the synthesis of various biaryl compounds with potential applications in pharmaceuticals, agrochemicals, and materials science.
Used in Preparation of Cellular Checkpoint Kinase Wee1 Binding Affectors:
2-Chloro-6-fluorophenylboronic acid is used as a key intermediate in the synthesis of cellular checkpoint kinase Wee1 binding affectors. These affectors are important for the development of potential therapeutic agents targeting the Wee1 kinase, which plays a crucial role in cell cycle regulation and has been implicated in various cancers. The unique substitution pattern of the compound allows for the creation of specific binding interactions with the target protein, contributing to the development of more effective and selective inhibitors.

Upstream product

• 5419-55-6 Triisopropyl borate 
• 625-98-9 3-chlorofluorobenzene 
• 121-43-7 Trimethyl borate 

Downstream Products

• 2225909-61-3 8-bromo-1-chlorodibenzo[b,d]furan 
• 1599432-38-8 2-(2-chloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1586041-22-6 N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2-chloro-6-fluorophenyl)thiazole-4-carboxamide 
• 1586041-18-0 5-amino-N-(5-((2S,5R,6R)-5-amino-6-methoxyoxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2-chloro-6-fluorophenyl)thiazole-4-carboxamide 
• 1586041-65-7 5-amino-N-(5-((2S,5R,6S)-5-amino-6-fluorooxepan-2-yl)-1-methyl-1H-pyrazol-4-yl)-2-(2-chloro-6-fluorophenyl)thiazole-4-carboxamide 

Relevant articles and documents

1' - Chloro -8 - bromine two benzofuran preparation method (by machine translation)

The invention discloses a high-efficient environmental protection of the 1 '- chloro - 8 - bromine two benzofuran preparation method, including: (1) butyl [...] chlorobenzene firstly the lithium pulls out the hydrogen, with triisopropyl borate undergo the