313657-05-5

Basic information

• Product Name: 1-(3-CHLORO-2-PYRAZINYL)-4-METHYLPIPERAZINE
• Synonyms: 1-(3-CHLORO-2-PYRAZINYL)-4-METHYLPIPERAZINE;2-Chloro-3-(4-Methylpiperazin-1-yl)pyrazine;2-Chloro-3-(4-methyl-1-piperazinyl)pyrazine
• CAS NO: 313657-05-5
• Molecular Formula: C₉H₁₃ClN₄
• Molecular Weight: 212.68
• Mol File: 313657-05-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 317.285°C at 760 mmHg
• Flash Point: 145.689°C
• Appearance: /
• Density: 1.243g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: 2-8°C
• PKA: 6.56±0.42(Predicted)
• CAS DataBase Reference: 1-(3-CHLORO-2-PYRAZINYL)-4-METHYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-CHLORO-2-PYRAZINYL)-4-METHYLPIPERAZINE(313657-05-5)
• EPA Substance Registry System: 1-(3-CHLORO-2-PYRAZINYL)-4-METHYLPIPERAZINE(313657-05-5)

Safety Data

• Hazardous Substances Data: 313657-05-5(Hazardous Substances Data)

Usage

Chemical structure

Piperazine derivative with a chloro-pyrazine group attached to the piperazine ring.

Common use

Pharmaceutical intermediate in the synthesis of pharmaceutical drugs.

Potential applications

Treating a variety of medical conditions, including neurological and psychiatric disorders.

Synthesis role

Building block in the synthesis of other organic compounds.

Additional use

Starting material in the production of various chemicals and pharmaceuticals.

InChI:InChI=1/C9H13ClN4/c1-13-4-6-14(7-5-13)9-8(10)11-2-3-12-9/h2-3H,4-7H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 4858-85-9 2,3-dichloropyrazine 

Relevant articles and documents

NOVEL COMPOUNDS AS ROR GAMMA MODULATORS

The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein ring A, ring B, L, R1, R2, R3, R4, R5, Ra, Rb, n, m, p and q are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.

Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases

Compounds of the general formula (I): wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2creceptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.