313657-51-1 Usage
Description
1-(2-Hydroxy-Phenyl)-Piperazin-4-Carboxylic Acid tert-Butyl Ester is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its hydroxyphenyl and piperazinyl groups, which contribute to its reactivity and potential applications in medicinal chemistry.
Uses
Used in Pharmaceutical Synthesis:
1-(2-Hydroxy-Phenyl)-Piperazin-4-Carboxylic Acid tert-Butyl Ester is used as an intermediate in the synthesis of 2-(1-Piperazinyl)-Benzenethiol (P480550), which is further used to prepare 3,5-Dioxo-(2H,4H)-1,2,4-Triazine derivatives. These derivatives act as 5-HT1AR ligands, playing a crucial role in the development of drugs targeting the serotonin receptor, which has implications in treating various neurological and psychiatric disorders.
Used in Osteoporosis Treatment:
1-(2-Hydroxy-Phenyl)-Piperazin-4-Carboxylic Acid tert-Butyl Ester is also utilized in the preparation of nonpeptidic biaryl inhibitors of human cathepsin K. These inhibitors are relevant to the treatment of osteoporosis, as they can help regulate bone resorption and maintain bone health by targeting the enzyme responsible for breaking down bone tissue.
Check Digit Verification of cas no
The CAS Registry Mumber 313657-51-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,3,6,5 and 7 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 313657-51:
(8*3)+(7*1)+(6*3)+(5*6)+(4*5)+(3*7)+(2*5)+(1*1)=131
131 % 10 = 1
So 313657-51-1 is a valid CAS Registry Number.
313657-51-1Relevant articles and documents
Affinity-Based Selectivity Profiling of an In-Class Selective Competitive Inhibitor of Acyl Protein Thioesterase 2
Won, Sang Joon,Eschweiler, Joseph D.,Majmudar, Jaimeen D.,Chong, Fei San,Hwang, Sin Ye,Ruotolo, Brandon T.,Martin, Brent R.
supporting information, p. 215 - 220 (2017/03/08)
Activity-based protein profiling (ABPP) has revolutionized the discovery and optimization of active-site ligands across distinct enzyme families, providing a robust platform for in-class selectivity profiling. Nonetheless, this approach is less straightfo
5HT1A ANTAGONIST USEFUL FOR IN VIVO IMAGING
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Page/Page column 26; 27, (2013/03/26)
The present invention provides a novel compound of formula (I) useful for in vivo imaging of 5-HT1 A receptors in a subject. Also provided by the present invention is a precursor compound useful in the preparation of the compound of the inventi
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor
Hoveyda, Hamid R.,Roy, Marie-Odile,Blanc, Sebastien,No?l, Sophie,Salvino, Joseph M.,Ator, Mark A.,Fraser, Graeme
scheme or table, p. 1991 - 1996 (2011/04/24)
A series of 3-aryl-5-acylpiperazinyl-pyrazoles (e.g., 3a-b) initially identified through a high-throughput screening campaign using the aequorin Ca2+ bioluminescence assay as novel, potent small molecule antagonists of the G protein-coupled hum
