313657-71-5

Basic information

• Product Name: 2-(2-bromopyridin-3-yloxy)ethanol
• Synonyms: 2-(2-bromopyridin-3-yloxy)ethanol;2-Bromo-3-(2-hydroxyethoxy)pyridine
• CAS NO: 313657-71-5
• Molecular Formula: C7H8BrNO2
• Molecular Weight: 218.049
• Mol File: 313657-71-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 329.733 °C at 760 mmHg
• Flash Point: 153.217 °C
• Appearance: /
• Density: 1.593±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(2-bromopyridin-3-yloxy)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromopyridin-3-yloxy)ethanol(313657-71-5)
• EPA Substance Registry System: 2-(2-bromopyridin-3-yloxy)ethanol(313657-71-5)

Safety Data

• Hazardous Substances Data: 313657-71-5(Hazardous Substances Data)

Usage

General Description

2-(2-Bromopyridin-3-yloxy)ethanol is a chemical compound that, as the name suggests, contains bromine and pyridine elements. Its Molecular Formula is C7H8BrNO2 and has a molecular weight of 230.05 g/mol. The compound is characterised by the presence of a bromopyridin-3-yl group and an ethoxy group, which are functional groups that significantly contribute to its chemical behavior and reactivity. 2-(2-Bromopyridin-3-yloxy)ethanol can potentially be used in chemical research or as an intermediate in various chemical reactions or processes in industries. However, no specific applications or uses of this chemical are widely reported, implying its use might be highly specialized.

InChI:InChI=1/C7H8BrNO2/c8-7-6(11-5-4-10)2-1-3-9-7/h1-3,10H,4-5H2

Upstream product

• 6602-32-0 2-bromo-pyridin-3-ol 
• 540-51-2 2-bromoethanol 
• 96-49-1 [1,3]-dioxolan-2-one 

Relevant articles and documents

Sequential alcohol oxidation/putative homo Claisen-Tishchenko-type reaction to give esters: A key process in accessing novel biologically active lactone macrocycles

We report an efficient methodology for the direct oxidative esterification of primary alcohols to diether-esters using pyridinium chlorochromate (PCC). Numerous studies were carried out to probe the reaction mechanism and at the same time optimize the reaction conditions. The reaction could be conducted with 1 equivalent of PCC and 1 equivalent of BF3·OEt2. Indications based on literature precedent were that the reaction may proceed via a sequential alcohol oxidation to the aldehyde followed by a putative Cr or boron catalyzed Claisen-Tishchenko-type reaction. Using this efficient methodology, we synthesized a family of novel diether-esters in very good yields; some of these molecules were subsequently tested against both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). In addition, we also disclose a new synthetic strategy for the synthesis of lactam macrocycles with potential biological activity. This methodology included the regioselective borylation of the ester substrate and a subsequent Suzuki-Miyaura coupling to obtain the desired lactam macrocycle.

Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases

Compounds of the general formula (I): wherein the variables are as defined in the specification are useful for the prophylaxis or treatment of serotonin-related, especially 5-HT2receptor-related, diseases in human beings or animals, particularly diseases related to the 5-HT2creceptor, especially diseases such as eating disorders, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctionions, and urinary disorders.