3137-83-5 Usage
General Description
3'-Isothiocyanatoacetanilide, also known as ITC-A, is a chemical compound with the formula C10H8N2O2S. It is a derivative of acetanilide that contains an isothiocyanate functional group attached to the 3' position of the phenyl ring. ITC-A is often used as a reagent in chemical synthesis and bioconjugation reactions. Its isothiocyanate moiety is reactive towards amine groups, allowing for the formation of stable thiourea linkages. This property makes ITC-A a valuable tool in the modification and labeling of biomolecules for various applications in biochemistry and molecular biology. Additionally, ITC-A has been studied for its potential anti-cancer properties, as isothiocyanates have been shown to exhibit anti-tumor effects in various cell lines and animal models. Overall, 3'-Isothiocyanatoacetanilide is a versatile chemical with diverse applications in both research and industry.
Check Digit Verification of cas no
The CAS Registry Mumber 3137-83-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,3 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3137-83:
(6*3)+(5*1)+(4*3)+(3*7)+(2*8)+(1*3)=75
75 % 10 = 5
So 3137-83-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2OS/c1-7(12)11-9-4-2-3-8(5-9)10-6-13/h2-5H,1H3,(H,11,12)
3137-83-5Relevant articles and documents
Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD)
Jeong, Kwi-Wan,Lee, Jung-Hun,Park, Sun-Mi,Choi, Joo-Hyung,Jeong, Dae-Youn,Choi, Dong-Hwa,Nam, Yeonju,Park, Jong-Hyeon,Lee, Kwang-Nyeong,Kim, Su-Mi,Ku, Jin-Mo
, p. 387 - 397 (2015/09/01)
Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of livestock caused by a highly variable RNA virus, foot-and-mouth disease virus (FMDV). One of the targets to suppress expansion of and to control FMD is 3D polymerase (FMDV 3Dpol). In this study, 2-amino-4-arylthiazole derivatives were synthesized and evaluated for their inhibitory activity against FMDV 3Dpol. Among them, compound 20i exhibited the most potent functional inhibition (IC50 = 0.39μM) of FMDV 3D polymerase and compound 24a (EC50=13.09 μM) showed more potent antiviral activity than ribavirin (EC50=1367 μM) and T1105 (EC50=347 μM) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain.
