313735-62-5

Basic information

• Product Name: 4-Bromo-1-isopropyl-1H-pyrazole
• Synonyms: 4-BroMo-1-isopropylpyrazole;4-bromo-1-propan-2-ylpyrazole;4-BROMO-1-ISOPROPYL-1H-PYRAZOLE(WX637345)
• CAS NO: 313735-62-5
• Molecular Formula: C₆H₉BrN₂
• Molecular Weight: 189.05
• Product Categories: Azoles;blocks;Bromides
• Mol File: 313735-62-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 213.539 °C at 760 mmHg
• Flash Point: 82.946 °C
• Appearance: /
• Density: 1.492 g/cm³
• Refractive Index: 1.5070 to 1.5110
• Storage Temp.: 2-8°C
• PKA: 0.25±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-1-isopropyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1-isopropyl-1H-pyrazole(313735-62-5)
• EPA Substance Registry System: 4-Bromo-1-isopropyl-1H-pyrazole(313735-62-5)

Safety Data

• Hazardous Substances Data: 313735-62-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-1-isopropyl-1H-pyrazole is a chemical compound with the molecular formula C6H9BrN2. It belongs to the class of organic compounds known as pyrazoles, which are characterized by a five-membered ring structure containing two nitrogen atoms and three carbon atoms. This particular compound contains a bromine atom and an isopropyl group attached to the pyrazole ring. It is primarily used as a building block in organic synthesis, particularly in the pharmaceutical industry where it can be incorporated into the structure of drug candidates. It is also used in research settings as a reagent in chemical reactions, and as a reference standard in analytical chemistry. The compound's properties and reactivity make it valuable for a range of applications in drug discovery and development, as well as in academic and industrial research.

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 75-26-3 isopropyl bromide 
• 75-03-6 ethyl iodide 
• 75-30-9 2-iodo-propane 

Downstream Products

• 879487-10-2 1-isopropylpyrazole-4-boronic acid pinacol ester 
• 313735-67-0 1-(propan-2-yl)-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (I), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment of diseases including heart (e.g. ischemic heart disease, congestive heart failure, and valvular heart disease), lung (e.g., lung inflammation, pneumonia, acute lung injury, pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease), respiratory (e.g., respiratory infection, acute respiratory distress syndrome), liver (e.g. acute liver failure and liver fibrosis and cirrhosis), and kidney (e.g. acute kidney injury and chronic kidney disease) disease, inflammatory bowel disease (IBD), ischemic reperfusion injury (e.g., stroke), and retinopathy of prematurity (ROP).

PYRAZOLE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to pyrazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the pyrazole compounds described herein in the potential treatment or prevention of neurological and psych

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).