31402-65-0

Basic information

• Product Name: 4-(2-aminopyrimidin-5-yl)nitrobenzene
• Synonyms: 4-(2-aminopyrimidin-5-yl)nitrobenzene
• CAS NO: 31402-65-0
• Molecular Weight: 216.199
• Mol File: 31402-65-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-aminopyrimidin-5-yl)nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-aminopyrimidin-5-yl)nitrobenzene(31402-65-0)
• EPA Substance Registry System: 4-(2-aminopyrimidin-5-yl)nitrobenzene(31402-65-0)

Safety Data

• Hazardous Substances Data: 31402-65-0(Hazardous Substances Data)

Upstream product

• 7752-82-1 5-bromo-2-aminopyrimidine 
• 24067-17-2 4-nitrophenylboronic acid 
• 936250-22-5 (2-aminopyrimidin-5-yl)boronic acid 
• 586-78-7 para-nitrophenyl bromide 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 31402-46-7 5-(4-amino-phenyl)-pyrimidin-2-ylamine 
• 201938-91-2 C₁₀H₇N₅O₄ 

Relevant articles and documents

New pyrimidylboronic acids and functionalized heteroarylpyrimidines by Suzuki cross-coupling reactions

We report the synthesis of 2-chloro-5-pyrimidylboronic acid (6) and 2-amino-5-pyrimidylboronic acid (8) by lithium-halogen exchange followed by reaction with triisopropylborate. Their reactivity with heteroaryl halides in Suzuki-Miyaura cross-coupling reactions has been evaluated. New highly functionalized 5-heteroarylpyrimidine derivatives 24-33 (heteroaryl = quinoline, pyridine, pyrimidine, pyrazine, thiophene, benzothiazole) have been obtained in synthetically useful yields. The X-ray structure of 6 reveals extensive intermolecular O-H...N hydrogen bonding in the crystal. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.