31408-56-7Relevant articles and documents
Precursor-directed combinatorial biosynthesis of cinnamoyl, dihydrocinnamoyl, and benzoyl anthranilates in saccharomyces cerevisiae
Eudes, Aymerick,Benites, Veronica Teixeira,Wang, George,Baidoo, Edward E.K.,Lee, Taek Soon,Keasling, Jay D.,Loqué, Dominique
, (2015/11/24)
Biological synthesis of pharmaceuticals and biochemicals offers an environmentally friendly alternative to conventional chemical synthesis. These alternative methods require the design of metabolic pathways and the identification of enzymes exhibiting ade
Traceless synthesis of 3H-quinazolin-4-ones via a combination of solid-phase and solution methodologies
O'Mahony, Donogh J.R.,Krchňák, Viktor
, p. 939 - 942 (2007/10/03)
A solid-phase traceless synthesis of quinazolin-4-ones is described. An aldehyde functionalized resin was reductively aminated with primary amines, and the resin-bound secondary amine acylated with o-nitro-benzoic acids. The nitro group was reduced with tin(II) chloride, and the aniline acylated with acid anhydrides. Acidolytic cleavage afforded a diamide, which was cyclized in solution phase to the 3H-quinazolin-4-one removing the trace of the linker.