31418-71-0 Usage
General Description
Coprogen is a type of siderophore, a molecule that binds and transports iron in microorganisms. Some bacteria and fungi produce coprogen to obtain iron from their environment, which is essential for their growth and survival. It is primarily produced in environments low in iron as it has a very high affinity for this metal. It is noteworthy for its importance in the context of microbial infections, as it allows the invading microorganisms to out-compete the host's cells for iron. The ability to produce siderophores like coprogen is hence deemed an important virulence factor in pathogenic microorganisms. Some studies also suggest that coprogen may carry potential for cancer therapy due to its iron-binding ability.
Check Digit Verification of cas no
The CAS Registry Mumber 31418-71-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,4,1 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 31418-71:
(7*3)+(6*1)+(5*4)+(4*1)+(3*8)+(2*7)+(1*1)=90
90 % 10 = 0
So 31418-71-0 is a valid CAS Registry Number.
InChI:InChI=1/C35H53N6O13.Fe/c1-23(11-17-42)20-30(45)39(51)14-5-8-27-33(48)38-28(34(49)37-27)9-6-15-40(52)32(47)22-25(3)13-19-54-35(50)29(36-26(4)44)10-7-16-41(53)31(46)21-24(2)12-18-43;/h20-22,27-29,42-43H,5-19H2,1-4H3,(H,36,44)(H,37,49)(H,38,48);/q-3;+3/b23-20-,24-21+,25-22-;
31418-71-0Relevant articles and documents
Coordination Chemistry of Microbial Iron Transport Compounds. 24. Characterization of Coprogen and Ferricrocin, Two Ferric Hydroxamate Siderophores
Wong, Geoffrey B.,Kappel, Mary J.,Raymond, Kenneth N.,Matzanke, B.,Winkelmann, G.
, p. 810 - 815 (1983)
The physical and thermodynamic properties of corpogen and ferricrocin, two hydroxamate siderophores produced by the fungus Neurospora crassa, have been examined.Formation constants determined by ethylenediaminetetraacetic acid (EDTA) competition reactions yielded the values logK* = 4.6 and 3.3 and logβ110 ca. 30.2 and 30.4, respectively, where K* = (3)/(3+>) and β110 = /(3+>3->), showing that these siderophores possess affinities for ferric ion similar to other hydroxamate ligands.Redox potentials of -447 and -412 mV vs.NHE, respectively, were found.Circular dichroism measurements have demonstrated that coprogen adopts primarily a Δ absolute configuration about the iron, whereas ferricrocin exists as the Λ isomer.
