3144-04-5

Basic information

• Product Name: butane-1-sulfonamide
• Synonyms: 1-Butanesulfonamide; Butane-1-sulfonamide
• CAS NO: 3144-04-5
• Molecular Formula: C₄H₁₁NO₂S
• Molecular Weight: 137.2006
• Mol File: 3144-04-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 241°C at 760 mmHg
• Flash Point: 99.5°C
• Density: 1.15g/cm³
• Vapor Pressure: 0.0368mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: butane-1-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: butane-1-sulfonamide(3144-04-5)
• EPA Substance Registry System: butane-1-sulfonamide(3144-04-5)

Safety Data

• Hazardous Substances Data: 3144-04-5(Hazardous Substances Data)

Usage

General Description

Butane-1-sulfonamide is a chemical compound that is also known as butanesulfonamide or 1-aminobutane-1-sulfonic acid. It is a sulfonamide derivative with the molecular formula C4H11NO2S. Butane-1-sulfonamide is primarily used as a building block in organic synthesis for the production of pharmaceuticals, agrochemicals, and other specialty chemicals. It is also used as a corrosion inhibitor for metal surfaces and as a component in the synthesis of certain polymers. Additionally, it has applications in the manufacturing of herbicides and insecticides. Overall, butane-1-sulfonamide plays an important role in various industrial processes and chemical applications.

Upstream product

• 109-65-9 1-bromo-butane 
• 3670-24-4 n-butylsulphonyl isocyanate 
• 109-72-8 n-butyllithium 
• 2386-60-9 perfluoro-1-butanesulfonyl fluoride 

Downstream Products

• 63884-88-8 (butane-1-sulfonyl)-carbamic acid pentyl ester 
• 105143-03-1 N-(butane-1-sulfonyl)-N'-p-tolyl-thiourea 
• 99988-10-0 N-(butane-1-sulfonyl)-N'-(4-nitro-phenyl)-urea 
• 5454-60-4 N-(butane-1-sulfonyl)-N'-p-tolyl-urea 
• 99857-78-0 N-(butane-1-sulfonyl)-N'-(4-chloro-phenyl)-thiourea 
• 101582-53-0 α--diphenylmethan 
• 910621-58-8 N-(1-butanesulfonyl)-2-phenylaziridine 
• 1159836-18-6 N-(butylsulfonyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 881652-46-6 3-methyl-4,5-dihydro-isothiazole 1,1-dioxide 
• 101258-21-3 (±)-3-methyl-1,2-thiazolidine 1,1-dioxide 
• 1609252-28-9 (Z)-N-(2-cyano-3-phenylprop-2-en-1-yl)-butanesulfonamide 
• 926299-62-9 N-(butylsulfonyl)-3-[1-(2,4-dichlorobenzyl)-3-isopropoxy-1H-pyrazol-5-yl]propanamide 
• 1159601-80-5 butane-1-sulfonic acid [6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridine-3-carbonyl]-amide 

Relevant articles and documents

Nickel complexes with phosphines and N-R-sulfonyldithiocarbimates ligands: New antifungals for the control of Hemileia vastatrix and Phakopsora pachyrhizi

Nickel(II) complexes of general formula [Ni(RSO2N = CS2)(PPh3)2] (2a–h) or [Ni(RSO2N = CS2)dppe] (3a–h), where R = methyl (a), ethyl (b), butyl (c), octyl (d), phenyl (e), 4-isopropylphenyl (f), 4-tert-butylphenyl (g), 2-naphthyl (h), PPh3 = triphenylphosphine and dppe = 1,2-bis(diphenylphosphine)ethane were prepared, from which six are new substances (2f–h and 3f–h). The new compounds were characterized by elemental analysis of C, H, N and Ni, and by IR, UV–Vis and 1H, 13C and 31P NMR spectroscopies. The data were consistent with the formation of square planar nickel(II) complexes with mixed ligands, what was confirmed by single crystal X-ray diffraction studies on compounds 2f and 2h. These complexes present intramolecular Ni–H–C anagostic interactions. All complexes inhibited the germination of Hemileia vastatrix and Phakopsora pachyrhizi, the causal agents of devastating diseases on soybean and coffee cultures. The most active compounds presented IC90 values as low as 405 μM against H. vastatrix, and 280 μM against P. pachyrhizi. Thus, the title compounds are target molecules for the development of new agrochemicals against the Asian soybean rust and Coffee leaf-rust diseases.

THIAZOLIDINONE COMPOUNDS AND USE THEREOF

A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

Synthesis, characterization, and antifungal activity of novel (Z)-N-(2-cyano-3-phenylprop-2-en-1-yl)-alkyl/aryl-sulfonamides derived from a Morita-Baylis-Hillman adduct

A series of allyl sulfonamides prepared from the reaction of the Morita-Baylis-Hillman adduct 2-[hydroxy(phenyl)methyl]acrylonitrile with primary sulfonamides (RSO2NH2), where R = C6H 5 (1), 4-FC6H4 (2), 4-ClC6H 4 (3), 4-BrC6H4 (4), 4-NO2C 6H4 (5), CH3 (6), CH3CH2 (7), CH3(CH2)3 (8), and CH3(CH 2)7 (9), were characterized by IR, 1H and 13C NMR spectroscopies, mass spectrometry and elemental analyses. BLYP/6-31G* calculations suggested stereoselective reactions, resulting in the exclusive formation of the thermodynamically more stable Z-products. The Z-configuration of the products was confirmed by NOE difference spectroscopy and single crystal X-ray diffraction measurements. The allyl sulfonamides were active against Colletotrichum gloeosporioides, an important agent of anthracnose in plants.