31502-35-9Relevant articles and documents
Ni-Catalyzed Regioselective β,δ-Diarylation of Unactivated Olefins in Ketimines via Ligand-Enabled Contraction of Transient Nickellacycles: Rapid Access to Remotely Diarylated Ketones
Basnet, Prakash,Dhungana, Roshan K.,Thapa, Surendra,Shrestha, Bijay,Kc, Shekhar,Sears, Jeremiah M.,Giri, Ramesh
supporting information, p. 7782 - 7786 (2018/06/22)
We disclose a [(PhO)3P]/NiBr2-catalyzed regioselective β, δ-diarylation of unactivated olefins in ketimines with aryl halides and arylzinc reagents. This diarylation proceeds at remote locations to the carbonyl group to afford, after simple H+ workup, diversely substituted β, δ-diarylketones that are otherwise difficult to access readily with existing methods. Deuterium-labeling and crossover experiments indicate that diarylation proceeds by ligand-enabled contraction of transient nickellacycles.
