3151-55-1Relevant articles and documents
Chlorin photosensitizers sterically designed to prevent self-aggregation
Uchoa, Adjaci F.,De Oliveira, Kleber T.,Baptista, Mauricio S.,Bortoluzzi, Adailton J.,Iamamoto, Yassuko,Serra, Osvaldo A.
, p. 8824 - 8832 (2011)
The synthesis and photophysical evaluation of new chlorin derivatives are described. The Diels-Alder reaction between protoporphyrin IX dimethyl ester and substituted maleimides furnishes endo-adducts that completely prevent the self-aggregation of the chlorins. Fluorescence, resonant light scattering (RLS) and 1H NMR experiments, as well as X-ray crystallographic have demonstrated that the configurational arrangement of the synthesized chlorins prevent π-stacking interactions between macrocycles, thus indicating that it is a nonaggregating photosensitizer with high singlet oxygen (ΦΔ) and fluorescence (Φf) quantum yields. Our results show that this type of synthetic strategy may provide the lead to a new generation of PDT photosensitizers.
MYCOBACTERIAL INHIBITORS
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Page/Page column 8, (2010/11/08)
The invention provides the use of certain succinimide compounds in the treatment of mycobacterial diseases.
COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF CYCLOOXYGENASE ACTIVITY
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, (2008/06/13)
The present invention includes N-substituted maleimides (1(H)-Pyrrole-2,5-dione (Maleimide) analogs and succinimides which act as potent nonsteroidal anti-inflammatory drugs and are capable of dual inactivation or selective inactivation of the cyclooxygenase and the peroxidase activities of prostaglandin endoperoxide synthase (PGHS).
