315241-05-5

Basic information

• Product Name: 4-chloro-2-(5-nitrothiazol-2-ylcarbamoyl)phenyl benzoate
• Synonyms: 4-chloro-2-(5-nitrothiazol-2-ylcarbamoyl)phenyl benzoate
• CAS NO: 315241-05-5
• Molecular Weight: 276.676
• Mol File: 315241-05-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-chloro-2-(5-nitrothiazol-2-ylcarbamoyl)phenyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-2-(5-nitrothiazol-2-ylcarbamoyl)phenyl benzoate(315241-05-5)
• EPA Substance Registry System: 4-chloro-2-(5-nitrothiazol-2-ylcarbamoyl)phenyl benzoate(315241-05-5)

Safety Data

• Hazardous Substances Data: 315241-05-5(Hazardous Substances Data)

Upstream product

• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1369700-98-0 C₁₇H₁₄ClN₃O₅S 
• 1417658-20-8 C₁₉H₁₅ClN₂O₄S 
• 1417658-19-5 5-chloro-2-hydroxy-N-(4-(phenylcarbamoyl)phenyl)benzamide 
• 1415566-84-5 C₁₇H₁₀ClN₃O₅S 
• 1426068-32-7 4-chloro-2-(5-nitrothiazol-2-ylcarbamoyl)phenyl benzoate 
• 10420-73-2 6-chloroflavone 
• 315241-28-2 C₁₄H₉O₄ClC₆H₁₄Si 

Relevant articles and documents

A Novel Synthesis of 4H-Chromen-4-ones via Intramolecular Wittig Reaction

formula presented The acylphosphoranes formed in a sequential manner from the reaction of the silyl ester of O-acyl(aroyl)salicylic acids and (trimethylsilyl)-methylenetriphenylphosphorane undergo intramolecular Wittig cyclization on the ester carbonyl to afford the 4H-chromen-4-ones in good to excellent yields.

Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis

Twenty eight 5-nitrothiazole derivatives were synthesized and evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity against HEK 293T. Among the compounds, 5-nitro-N-(5-nitrothiazol-2-yl)furan-2- carboxamide (20) was found to be the most active compound in vitro with MICs of 5.48 μM against log-phase culture of MTB and also non-toxic up to 100 μM.