315674-93-2Relevant articles and documents
Convenient procedures for synthesis of ciproxifan, a histamine H3-receptor antagonist
Stark, Holger
, p. 315 - 316 (2007/10/03)
Cyclopropyl 4-(3-(1H-imidazol-4-yl)propyloxy)phenyl methanone (ciproxifan) is a novel reference antagonist for the histamine H3 receptor. Despite the former Mitsunobu reaction the actual key reaction for preparation based on S(N)Ar for acylated fluoroaromatics with an additional cyclization in a one-pot procedure needs no chromatographic purification steps and results in good yields.
Novel histamine H3-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds
Stark,Sadek,Krause,Huls,Ligneau,Ganellin,Arrang,Schwartz,Schunack
, p. 3987 - 3994 (2007/10/03)
Novel histamine H3-receptor antagonists possessing a 4-(3-(phenoxy)propyl)-1H-imidazole structure generally substituted in the para-position of the phenyl ring have been synthesized according to Mitsunobu or S(N)Ar reactions. With in vitro and