31609-42-4

Basic information

• Product Name: 1-(4-METHYL-2-PHENYLAMINO-THIAZOL-5-YL)-ETHANONE
• Synonyms: 1-[4-Methyl-2-(phenylamino)-1,3-thiazol-5-yl]ethan-1-one 98%;5-Acetyl-4-methyl-2-(phenylamino)-1,3-thiazole, 5-Acetyl-2-anilino-4-methyl-1,3-thiazole;1-[4-Methyl-2-(phenylamino)-1,3-thiazol-5-yl]ethan-1-one98%
• CAS NO: 31609-42-4
• Molecular Formula: C₁₂H₁₂N₂OS
• Molecular Weight: 232.31
• Mol File: 31609-42-4.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-METHYL-2-PHENYLAMINO-THIAZOL-5-YL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHYL-2-PHENYLAMINO-THIAZOL-5-YL)-ETHANONE(31609-42-4)
• EPA Substance Registry System: 1-(4-METHYL-2-PHENYLAMINO-THIAZOL-5-YL)-ETHANONE(31609-42-4)

Safety Data

• Hazardous Substances Data: 31609-42-4(Hazardous Substances Data)

Usage

General Description

"1-(4-Methyl-2-phenylamino-thiazol-5-yl)-ethanone" is a chemical compound with a molecular formula C13H12N2OS. It belongs to the thiazole class of compounds and is commonly used as an intermediate in the synthesis of pharmaceuticals and organic materials. The compound is characterized by its thiazole ring structure with an attached ethanone group and a methyl-phenylamino substituent. It may have various applications in the pharmaceutical and chemical industries, including potential use as a building block for the development of new drugs or as a reagent in organic synthesis processes. Due to its specific structural and chemical properties, "1-(4-Methyl-2-phenylamino-thiazol-5-yl)-ethanone" may have diverse potential uses and applications in various scientific and industrial fields.

Upstream product

• 109044-35-1 N-(5-acetyl-4-methyl-thiazol-2-yl)-N-phenyl-acetamide 
• 64-17-5 ethanol 
• 1132-44-1 1-acetyl-3-phenylthiourea 
• 121-44-8 triethylamine 
• 78-95-5 chloroacetone 
• 75-09-2 dichloromethane 
• 3043-28-5 3-bromopentane-2,4-dione 
• 103-85-5 monophenylthiourea 
• 333-20-0 potassium thioacyanate 
• 62-53-3 aniline 
• 1694-29-7 3-chloropentane-2,4-dione 
• 123-54-6 acetylacetone 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 112833-20-2 (E)-1-(4-Methyl-2-phenylamino-thiazol-5-yl)-3-p-tolyl-propenone 
• 112833-18-8 (E)-3-(2-Hydroxy-phenyl)-1-(4-methyl-2-phenylamino-thiazol-5-yl)-propenone 
• 112833-19-9 (E)-3-(4-Bromo-phenyl)-1-(4-methyl-2-phenylamino-thiazol-5-yl)-propenone 
• 88324-03-2 1-(4-Methyl-2-phenylamino-thiazol-5-yl)-ethanone oxime 
• 1257438-64-4 1-(2-phenylamino-4-methyl-thiazole-5-yl)-3-(4-chlorophenyl)-propen-1-one 
• 1257438-63-3 1-(2-phenylamino-4-methyl-thiazole-5-yl)-3-(2-chlorophenyl)-propen-1-one 
• 1257438-65-5 1-(2-phenylamino-4-methyl-thiazole-5-yl)-3-(3,4,5-trimethoxyphenyl)-propen-1-one 
• 1257438-62-2 1-(2-phenylamino-4-methyl-thiazole-5-yl)-3-phenyl-propen-1-one 
• 1257438-61-1 1-(2-phenylamino-4-methyl-thiazole-5-yl)-3-(3-methoxyphenyl)-propen-1-one 
• 1333391-55-1 3-dimethylamino-1-[4-methyl-2-(methyl(phenyl)amino)thiazol-5-yl]propenone 
• 1333391-51-7 {4-[2-(phenyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-(4-fluorophenyl)amine 
• 1333391-44-8 {4-[2-(phenyl(methyl)amino)-4-methylthiazol-5-yl]pyrimidin-2-yl}-(3-methoxyphenyl)amine 
• 88324-19-0 3-Hydroxy-2,4'-dimethyl-2'-phenylamino-2,3-dihydro-[2,5']bithiazolyl-4-one 
• 112834-23-8 {4-Methyl-5-[5-(4-nitro-phenyl)-4,5-dihydro-isoxazol-3-yl]-thiazol-2-yl}-phenyl-amine 

Relevant articles and documents

Mechanochemical synthesis of 5-acetylthiazole: A step toward green and sustainable chemistry

Mechanochemical synthesis of 5-acetylthiazole derivatives by one-pot three-component procedure over Silica Sulfuric acid under solvent-free conditions, has been developed. The durability of the catalyst was tested. The environmentally benign protocol introduced herein characterized by no hazardous organic solvent used, recyclability of the catalyst up to five runs without loss of its catalytic activity and high yields of products that confirm the utilization of some green chemistry principles in the mentioned protocol.

Visible Light-Mediated Coupling of Thioureas and 1,3-Dicarbonyls: Towards a Leaving Group-Free Synthesis of Aminothiazoles

A synthesis of aminothiazoles from various 1,3-dicarbonyls and thioureas without a leaving group has been developed. The reaction is photocatalyzed by tetraiodofluorescein, an organic dye. Under irradiation with green LEDs, a sulfur radical is generated in situ from thiourea, followed by addition to the enol tautomer, forming the aminothiazole backbone. This novel strategy provides a greener alternative to the traditional leaving group protocols, with excellent atom economy. (Figure presented.).

Synthesis of 5-acetyl-2-arylamino-4-methylthiazole thiosemicarbazones under microwave irradiation and their in vitro anticancer activity

A series of 21 new tri- and tetra-cyclic thiosemicarbazone derivatives were prepared via the condensation of morpholine, piperazine or N-(4-methoxyphenyl)piperazine with seven methyl hydrazine-carbodithioate derivatives of 5-acetyl-2-arylamino-4-methylthiazoles under microwave irradiation. All compounds were tested for their cytotoxic activity in vitro against human gastric, lung and breast cancer cell lines. The results showed that some of the compounds displayed moderate anticancer activity. The most potent compound, a morpholinosubstituted analogue, exhibited significant activity against human breast cancer cells.