316173-28-1

Basic information

• Product Name: (3aR,4R,6S,6aS)-4-(tert-butoxycarbonylaMino)-3-(pentan-3-yl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylic acid
• Synonyms: (3aR,4R,6S,6aS)-4-(tert-butoxycarbonylaMino)-3-(pentan-3-yl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylic acid;2-Methylpropan-2-aMine(3aR,4R,6S)-4-((tert-butoxycarbonyl)aMino)-3-(pentan-3-yl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylate;(3aR,4R,6S,6aS)-4-[(2-methylpropan-2-yl)oxycarbonylamino]-3-pentan-3-yl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,2]oxazole-6-carboxylate,tert-butylazanium
• CAS NO: 316173-28-1
• Molecular Formula: C17H28N2O5
• Molecular Weight: 340.41462
• EINECS: 1312995-182-4
• Mol File: 316173-28-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3aR,4R,6S,6aS)-4-(tert-butoxycarbonylaMino)-3-(pentan-3-yl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,4R,6S,6aS)-4-(tert-butoxycarbonylaMino)-3-(pentan-3-yl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylic acid(316173-28-1)
• EPA Substance Registry System: (3aR,4R,6S,6aS)-4-(tert-butoxycarbonylaMino)-3-(pentan-3-yl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylic acid(316173-28-1)

Safety Data

• Hazardous Substances Data: 316173-28-1(Hazardous Substances Data)

Usage

General Description

The chemical "(3aR,4R,6S,6aS)-4-(tert-butoxycarbonylamino)-3-(pentan-3-yl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylic acid" is a compound with a complex molecular structure. It contains a cyclopenta[d]isoxazole ring system and a carboxylic acid group. Additionally, it has an amino group protected by a tert-butoxycarbonyl (Boc) group. The compound also has a pentan-3-yl side chain attached to the cyclopenta[d]isoxazole ring. This chemical may have potential pharmaceutical applications, particularly in the development of new drugs or research into the biological effects of similar compounds.

Upstream product

• 75-64-9 tert-butylamine 
• 168683-02-1 (1S,4R)-(-)-methyl-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopent-2-ene-1-carboxylate 

Downstream Products

• 229613-93-8 (+)-methyl (3aR,4R,6S,6aS)-4-[(tert-butoxycarbonyl)-amino]-3-(1-ethylpropyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d]isoxazole-6-carboxylate 

Relevant articles and documents

Method for preparing peramivir intermediate

The invention discloses a method for preparing a peramivir intermediate. The method comprises the steps that 1, in the presence of a compound shown as the formula C and triethylamine, (1S,4R)-(-)-methyl-[[(1,1-dimethyl oxethyl)carbonyl]amidogen]cyclopentene-2-alkene-1-methyl heptine carbonate and 2-ethyl-N-hydroxyl imide chloride are subjected to a contact reaction in THF, after the reaction is finished, a sodium hydroxide water solution is added into reaction liquid, reacting is carried out for 2-3 hours, the pH is adjusted to range from 5 to 7, extraction and concentration are carried out, washing is carried out with cold ethyl alcohol, and (3aR,4R,6S,6aS)-4-[[(1,1-dimethyl oxethyl)carbonyl]amidogen]-3-(1'-ethyl propyl)-3a,5,6,6a-tetralin-4H-cyclopentane[d]-isoxazole-6-carboxylic acid is obtained; 2, the product obtained in the step 1 is dissolved in dichloromethane, then tert-butylamine is added, stirring and reacting are carried out for 2 hours at the temperature of 5 DEG C to 15 DEG C, concentration is carried out, washing is carried out with cold ethyl alcohol, and drying is carried out to obtain the peramivir intermediate. The method for preparing the peramivir intermediate is high in yield, and the reaction time is greatly shortened.