31642-67-8 Usage
Description
8-Nonenoic acid, also known as 8-nonenoate, is a naturally occurring unsaturated fatty acid with a unique structure featuring an eight-carbon chain and a terminal double bond. It is characterized by its distinct chemical properties, which include a carboxylic acid group and a double bond that can participate in various chemical reactions. This organic compound has garnered interest due to its potential applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
8-Nonenoic acid is used as a reagent for the synthesis of 4-N-Alkyl Gemcitabine (G305000) analogs, which are antineoplastic agents. These analogs have demonstrated potential in the treatment of various types of cancer by inhibiting key enzymes involved in DNA synthesis and cell division, thereby disrupting the growth and proliferation of cancer cells.
In the synthesis process, 8-nonenoic acid serves as a key building block, providing the necessary structural framework for the formation of the final Gemcitabine analog. Its unique chemical properties, such as the carboxylic acid group and the double bond, enable it to participate in various chemical reactions, making it an essential component in the synthesis of these potent antineoplastic agents.
Furthermore, the use of 8-nonenoic acid in the synthesis of Gemcitabine analogs highlights its potential as a versatile reagent in the development of novel therapeutic agents for cancer treatment. As research continues to explore the properties and applications of this compound, it is likely that 8-nonenoic acid will play an increasingly important role in the pharmaceutical industry, contributing to the development of new and innovative treatments for various diseases, including cancer.
Synthesis Reference(s)
Synthetic Communications, 9, p. 63, 1979 DOI: 10.1080/00397917908064130
Check Digit Verification of cas no
The CAS Registry Mumber 31642-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,6,4 and 2 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 31642-67:
(7*3)+(6*1)+(5*6)+(4*4)+(3*2)+(2*6)+(1*7)=98
98 % 10 = 8
So 31642-67-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H16O2/c1-2-3-4-5-6-7-8-9(10)11/h2H,1,3-8H2,(H,10,11)
31642-67-8Relevant articles and documents
Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
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Page/Page column 7-10; 26; 27, (2015/04/21)
The invention provides a process of preparing 4-amino-4-oxobutanoyl peptides and cyclic analogues thereof of Compound I and pharmaceutically acceptable salts thereof.
Novel regioselective hydrogenation of alkadienoic acids caused by the addition of water
Okano, Temon,Kaji, Mitsunari,Isotani, Satoru,Kiji, Jitsuo
, p. 5547 - 5550 (2007/10/02)
The regioselective hydrogenation of 3,8-nonadienoic acid to 8-nonenoic acid was realized by the addition of water with RhCl[P(p-tolyl)3]3 in benzene at 1 atm hydrogen, whereas in the absence of water the reaction mostly gave 3-nonenoic acid. The novel selectivity is caused by both an accelerating effect of water on the hydrogenation of the 3-position and a retarding effect on that of the 8-position.
