31690-11-6

Basic information

• Product Name: 5,10-Methylene-THF
• Synonyms: 5,10-Methylene-THF
• CAS NO: 31690-11-6
• Molecular Formula: C₂₀H₂₃N₇O₆
• Molecular Weight: 457.43992
• Mol File: 31690-11-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.75g/cm³
• Refractive Index: 1.8
• PKA: 3.47±0.10(Predicted)
• CAS DataBase Reference: 5,10-Methylene-THF(CAS DataBase Reference)
• NIST Chemistry Reference: 5,10-Methylene-THF(31690-11-6)
• EPA Substance Registry System: 5,10-Methylene-THF(31690-11-6)

Safety Data

• Hazardous Substances Data: 31690-11-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12-,13?/m1/s1

Upstream product

• 135-16-0 tetrahydrofolic acid 
• 50-00-0 formaldehyd 
• 7732-18-5 water 
• 142811-51-6 N-<4-<<2(S)-amino-3-<(2,5-diamino-4(3H)-oxopyrimidin-6-yl)amino>propyl>amino>benzoyl>-L-glutamic acid 
• 142811-49-2 N-<4-<<2(S)--3-<(2-amino-5-nitro-4(3H)-oxopyrimidin-6-yl)amino>propyl>amino>benzoyl>-L-glutamic acid 
• 142811-46-9 2-amino-6<<2'(R)-(benzylamino)-3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone 
• 142811-47-0 2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone 
• 142811-48-1 [(R)-2-(2-Amino-5-nitro-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-1-formyl-ethyl]-benzyl-carbamic acid tert-butyl ester 
• 142811-50-5 N-<4-<<2(S)-(benzylamino)-3-<(2-amino-5-nitro-4(3H)-oxopyrimidin-6-yl)amino>propyl>amino>benzoyl>-L-glutamic acid 
• 59-30-3 folate 
• 135-16-0 (6S,S)-5,6,7,8-tetrahydrofolic acid 
• 64-18-6 formic acid 

Downstream Products

• 31690-09-2 (6S)-N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-4-oxo-5-methyl-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid 
• 365-07-1 thymidine 5'-phosphate 
• 5238-86-8 5-(hydroxymethyl)-2′-deoxyuridine-5′-monophosphate 

Relevant articles and documents

Process for preparing L-5 - methyl tetrahydrofolinate

The invention relates to a preparation process of L-5 - methyl tetrahydrofolic acid, which adopts asymmetric catalytic hydrogenation to convert folic acid into (6S) - tetrahydro folic acid, and has high folic acid conversion rate, and (6S) - tetrahydrofolic acid diastereomeric excess degree. By salt formation and crystallization, the (6S) - tetrahydrofolic acid intermediate with extremely high diastereomeric excess can be easily enriched, and thus the yield and purity of L-5 - methyltetrahydrofolinate finally obtained are high. The catalytic hydrogenation process is very mature in industrial application and convenient to operate. The subsequent methylation and salt formation steps are easy to implement, and the preparation process has high economic value and practical value under the condition that the yield and purity of the product are improved.