31692-85-0 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 31692-85-0 differently. You can refer to the following data:
1. liquid
2. Glycofurol is a clear, colorless, almost odorless liquid, with a bitter
taste; it produces a warm sensation on the tongue.
Uses
Different sources of media describe the Uses of 31692-85-0 differently. You can refer to the following data:
1. Glycofurol is used as a carrier device for drug delivery.
2. Used as solvent to dissolve water-insoluble compounds.
Production Methods
Glycofurol is prepared by the reaction of tetrahydrofurfuryl alcohol
with ethylene oxide (followed by a special purification process in
the case of Glycofurol 75).
Pharmaceutical Applications
Glycofurol is used as a solvent in parenteral products for
intravenous or intramuscular injection in concentrations up to
50% v/v. It has also been investigated, mainly in animal studies,
for use as a penetration enhancer and solvent in topical and
intranasal formulations. Glycofurol has also been used at 20%
v/v concentration in a rectal formulation.
Safety
Glycofurol is mainly used as a solvent in parenteral pharmaceutical
formulations and is generally regarded as a relatively nontoxic and
nonirritant material at the levels used as a pharmaceutical excipient.
Glycofurol can be irritant when used undiluted; its tolerability is
approximately the same as propylene glycol.
Glycofurol may have an effect on liver function and may have a
low potential for interaction with hepatoxins or those materials
undergong extensive hepatic metabolism.
LD50 (mouse, IV): 3.5 mL/kg
storage
Stable if stored under nitrogen in a well-closed container protected
from light, in a cool, dry place.
Incompatibilities
Incompatible with oxidizing agents.
Regulatory Status
Included in parenteral medicines licensed in Europe.
Check Digit Verification of cas no
The CAS Registry Mumber 31692-85-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,6,9 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 31692-85:
(7*3)+(6*1)+(5*6)+(4*9)+(3*2)+(2*8)+(1*5)=120
120 % 10 = 0
So 31692-85-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H14O3/c8-3-5-9-6-7-2-1-4-10-7/h7-8H,1-6H2
