31747-59-8 Usage
Description
5-IODO-2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE SODIUM is a 2'-deoxycytidine phosphate derivative in which the hydrogen at position 5 on the cytosine ring is replaced by iodine. It is a nucleotide analog that plays a significant role in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
5-IODO-2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE SODIUM is used as a therapeutic agent for its potential anti-cancer properties. It may be employed in the development of targeted cancer treatments, as it can interfere with the replication and transcription processes of cancer cells, leading to their inhibition or death.
Used in Research and Development:
In the field of research, 5-IODO-2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE SODIUM serves as an essential tool for studying the mechanisms of DNA and RNA synthesis, as well as the effects of nucleotide analogs on cellular processes. It can be used to investigate the role of specific nucleotides in gene expression and regulation.
Used in Diagnostic Applications:
5-IODO-2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE SODIUM can be utilized in the development of diagnostic tools and tests, such as those used to detect specific genetic mutations or to monitor the progression of certain diseases. Its unique properties may allow for the creation of more sensitive and accurate diagnostic methods.
Used in Biotechnology:
In the biotechnology industry, 5-IODO-2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE SODIUM may be employed in the development of novel bioproducts, such as enzymes or other proteins with altered functions. Its incorporation into biological systems can lead to the creation of new biocatalysts or biosensors with improved performance.
Used in Nanotechnology:
5-IODO-2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE SODIUM can also be used in the field of nanotechnology, where it may be incorporated into nanoscale devices or materials for various applications, such as drug delivery, imaging, or sensing. Its unique chemical properties can contribute to the development of innovative nanosystems with enhanced capabilities.
Check Digit Verification of cas no
The CAS Registry Mumber 31747-59-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,4 and 7 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 31747-59:
(7*3)+(6*1)+(5*7)+(4*4)+(3*7)+(2*5)+(1*9)=118
118 % 10 = 8
So 31747-59-8 is a valid CAS Registry Number.
31747-59-8Relevant articles and documents
Methoxyphenol and dihydrobenzofuran as oxidizable labels for electrochemical detection of DNA
Simonova, Anna,Balintov, Jana,Pohl, Radek,Havran, Ludk,Fojta, Miroslav,Hocek, Michal
, p. 1703 - 1712 (2014)
4-Hydroxy-3-methoxyphenyl (MOP) and 2,3-dihydrobenzofuran- 5-yl (DHB) groups were tested as potential new oxidizable labels for electrochemical detection of DNA. The corresponding 5-aryl-cytosine and 7-aryl-7-deazaadenine 2′-deoxyribonucleoside triphospha
Exploiting Substrate Promiscuity to Develop Activity-Based Probes for Ten-Eleven Translocation Family Enzymes
Ghanty, Uday,Denizio, Jamie E.,Liu, Monica Yun,Kohli, Rahul M.
, p. 17329 - 17332 (2018)
Ten-eleven translocation (TET) enzymes catalyze repeated oxidations of 5-methylcytosine in genomic DNA. Because of the challenges of tracking reactivity within a complex DNA substrate, chemical tools to probe TET activity are limited, despite these enzyme's crucial role in epigenetic regulation. Here, building on precedents from related Fe(II)/α-ketoglutarate-dependent dioxygenases, we show that TET enzymes can promiscuously act upon cytosine bases with unnatural 5-position modifications. Oxidation of 5-vinylcytosine (vC) in DNA results in the predominant formation of a 5-formylmethylcytosine product that can be efficiently labeled to provide an end-point read-out for TET activity. The reaction with 5-ethynylcytosine (eyC), moreover, results in the formation of a high-energy ketene intermediate that can selectively trap any active TET isoform as a covalent enzyme-DNA complex, even in the complex milieu of a total cell lysate. Exploiting substrate promiscuity therefore offers a new and needed means to directly track TET activity in vitro or in vivo.
A new efficient stereoselective method for the synthesis of (E)-5-aminoallyl-pyrimidine-5′-triphosphates using palladium-catalyzed heck reaction
Kore, Anilkumar R.,Senthilvelan, Annamalai,Shanmugasundaram, Muthian,Sandoval, David,Pardo, Andrew
, p. 221 - 228 (2015/04/27)
An efficient overall two-step strategy for the synthesis of, starting from commercially available pyrimidine-5′-triphosphate is described. The method involves regioselective iodination of pyrimidine-5′-triphosphate, followed by the palladium-catalyzed Heck coupling with allylamine. The catalytic reaction is highly stereoselective and compatible with many functional groups present in the reactants.
