31772-06-2Relevant articles and documents
Electrostatic Control of Macrocyclization Reactions within Nanospaces
Wang, Kaiya,Cai, Xiaoyang,Yao, Wei,Tang, Du,Kataria, Rhea,Ashbaugh, Henry S.,Byers, Larry D,Gibb, Bruce C.
supporting information, p. 6740 - 6747 (2019/05/06)
The intrinsic structural complexity of proteins makes it hard to identify the contributions of each noncovalent interaction behind the remarkable rate accelerations of enzymes. Coulombic forces are evidently primary, but despite developments in artificial nanoreactor design, a picture of the extent to which these can contribute has not been forthcoming. Here we report on two supramolecular capsules that possess structurally identical inner-spaces that differ in the electrostatic potential (EP) field that envelops them: one positive and one negative. This architecture means that only changes in the EP field influence the chemical properties of encapsulated species. We quantify these influences via acidity and rates of cyclization measurements for encapsulated guests, and we confirm the primary role of Coulombic forces with a simple mathematical model approximating the capsules as Born spheres within a continuum dielectric. These results reveal the reaction rate accelerations possible under Coulombic control and highlight important design criteria for nanoreactors.
Dynamic assessment of bilayer thickness by varying phospholipid and hydraphile synthetic channel chain lengths
Weber, Michelle E.,Schlesinger, Paul H.,Gokel, George W.
, p. 636 - 642 (2007/10/03)
A library of "hydraphile" synthetic ion channel analogues that differ in overall length from ~28-58 A has been prepared. A new and convenient ion-selective electrode (ISE) method was used to assay Na+ release. Liposomes were formed from three d
Iron-tetraphenylporphine complex having phosphocholine group
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, (2008/06/13)
Disclosed is an iron-5,10,15,20-tetra(α, α, α, α-o-substituted phenyl)porphine complex having one or four substituents with a phosphocholine group at the terminal end thereof. The substituents are positioned ortho of the phenyl group or groups.