31793-07-4 Usage
Originator
Rengasil, Ciba Geigy ,France ,1981
Uses
Different sources of media describe the Uses of 31793-07-4 differently. You can refer to the following data:
1. Anti-inflammatory.
2. Pirprofen is a non-steroidal anti-inflammatory drug.
Manufacturing Process
To the mixture of 85.5 g ethyl α-(3-chloro-4-aminophenyl)-propionate hydrochloride, 142 g sodium carbonate and 600 ml dimethyl formamide, 107g 1,4-dibromo-2-butene are added dropwise while stirring and the whole is refluxed for 5 hours and allowed to stand overnight at room temperature. The mixture is filtered, the filtrate evaporated in vacuo, the residue is triturated with hexane, the mixture filtered, the residue washed with petroleum ether and the filtrate evaporated. The residue is combined with 280 ml 25% aqueous sodium hydroxide and the mixture refluxed for 8 hours. After cooling, it is diluted with water, washed with diethyl ether, the pH adjusted to 5 to 5.2 with hydrochloric acid and extracted with diethyl ether. The extract is dried, filtered, evaporated and the residue crystallized from benzene-hexane, to yield the α-(3-chloro-4-pyrrolinophenyl)-propionic acid melting at 94°C to 96°C.
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
Pirprofen, a nonsteroidal anti-inflammatory agent, was introduced
in 1982 primarily for the treatment of rheumatic diseases, as well as for use in posttraumatic
and post-operative inflammatory conditions, acute gout and
dysmenorrhoea. Reports of serious adverse effects, in particular cases of liver
toxicity, some of which were fatal, led the manufacturer, in 1985 and in 1989, to
amend the approved product information of the drug, limiting duration of treatment
and lowering the recommended doses. In the light of these successive restrictions,
which have considerably reduced the field of application of pirprofen and in view of
available alternatives, the manufacturer has decided to discontinue the drug
worldwide.
Check Digit Verification of cas no
The CAS Registry Mumber 31793-07-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,9 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 31793-07:
(7*3)+(6*1)+(5*7)+(4*9)+(3*3)+(2*0)+(1*7)=114
114 % 10 = 4
So 31793-07-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H14ClNO2/c1-9(13(16)17)10-4-5-12(11(14)8-10)15-6-2-3-7-15/h2-5,8-9H,6-7H2,1H3,(H,16,17)
31793-07-4Relevant articles and documents
Esters and amides containing the 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl moiety
-
, (2008/06/13)
Compounds of the formula STR1 wherein each X, which may be identical or different from the other X, is oxygen or imino; R1 is hydrogen, fluorine, chlorine or bromine; R2 and R3, which may be identical or different from each other, are each hydrogen; unsubstituted or mono-substituted alkyl of 1 to 6 carbon atoms, where the substituent is phenyl or dialkylamino with 1 to 3 carbon atoms in each alkyl moiety; pyridyl; or cycloalkyl of 5 to 7 carbon atoms; R2 and R3, together with each other and the nitrogen atoms to which they are attached, are pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-aryl-piperazino or N-(alkyl of 1 to 3 carbon atoms)-piperazino; A is cycloalkylene of 5 to 7 carbon atoms; unsubstituted or substituted alkylene of 2 to 10 carbon atoms, where the substituents are one to two alkyls of 1 to 3 carbon atoms each, one to two carbalkoxys of 2 to 4 carbon atoms each, one to two phenyls, one to four hydroxyls, one halomethyl, one hydroxymethyl, one alkanoyloxy of 1 to 18 carbon atoms, one alkanoyloxymethyl of 1 to 18 carbon atoms in the alkanoyl moiety or one STR2 where R1, R2 and R3 have the meanings previously defined; or alkylene of 2 to 10 carbon atoms interrupted by oxygen, sulfur, sulfoxide, sulfonyl, phenyl, cyclohexyl, pyridyl, piperazino or unsubstituted or substituted imino, where the substituent on the imino group is alkyl of 1 to 6 carbon atoms, phenyl or phenylalkyl of 1 to 3 carbon atoms in the alkyl moiety; B is the acyl residue of an antiphlogistic carboxylic acid; and their non-toxic, pharmacologically acceptable acid addition salts. The compounds as well as their salts are useful as anti-inflammatories.
