31795-61-6 Usage
Description
6-(Hydroxymethyl)nicotinonitrile is a chemical compound derived from 5-Cyano-2-methylpyridine (C981875). It is characterized by the presence of a nitrile group and a hydroxymethyl group attached to a pyridine ring. 6-(HYDROXYMETHYL)NICOTINONITRILE is known for its potential applications in the synthesis of various biologically active molecules and as a research tool in enzyme-related studies.
Uses
Used in Pharmaceutical Synthesis:
6-(Hydroxymethyl)nicotinonitrile is used as a key intermediate in the synthesis of acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH). IMPDH is an important enzyme involved in the regulation of immune responses, and its inhibition can lead to the development of novel immunosuppressive agents.
Used in Enzyme Inhibitor Development:
6-(HYDROXYMETHYL)NICOTINONITRILE is also utilized in the preparation of potent and selective nonpeptidic inhibitors of procollagen C-proteinase. Procollagen C-proteinase is a crucial enzyme in the processing of collagen, a major structural protein in the extracellular matrix. Inhibitors targeting this enzyme can have potential applications in the treatment of various connective tissue disorders and fibrosis.
Used in Pyruvate Dehydrogenase (PDH) Research:
6-(Hydroxymethyl)nicotinonitrile is suitable for pyruvate dehydrogenase (PDH) related research. PDH is a mitochondrial enzyme complex that plays a central role in cellular metabolism by converting pyruvate to acetyl-CoA. Studying the interactions of this compound with PDH can provide insights into the regulation of cellular energy production and the development of therapeutic agents targeting metabolic disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 31795-61-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,7,9 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 31795-61:
(7*3)+(6*1)+(5*7)+(4*9)+(3*5)+(2*6)+(1*1)=126
126 % 10 = 6
So 31795-61-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O/c8-3-6-1-2-7(5-10)9-4-6/h1-2,4,10H,5H2
31795-61-6Relevant articles and documents
BENZIMIDAZOLE DERIVATIVES AND THEIR USES
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Page/Page column 98, (2019/05/10)
The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising
BENZISOXAZOLE COMPOUND
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Page/Page column 167, (2009/02/10)
Disclosed is a compound represented by the general formula (I) or a salt thereof: wherein any one of R1, R2 and R3 represents a group represented by the formula: -(CH2)m-NR11R12 (wherein m is 1 or 2; and R11 and R12 independently represent a hydrogen atom or a C1-6 alkyl group or may, together with a nitrogen atom to which R11 and R12 are bound, form a 4- or 5-membered cyclic group); the remaining two or R1, R2 and R3 independently represent a group represented by the formula: -(O)n-R21 (wherein n is 0 or 1; and R21 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the like); and R4 represents a C1-6 alkyl group which may have a substituent or the like.
DIHYDROPYRIDINE DERIVATIVES FOR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
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Page 47, (2010/02/06)
The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
