31815-61-9

Basic information

• Product Name: 1-methyl-2-(o-tolyl)-1H-benzo[d]imidazole
• Synonyms: 1-methyl-2-(o-tolyl)-1H-benzo[d]imidazole
• CAS NO: 31815-61-9
• Molecular Weight: 222.29
• Mol File: 31815-61-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1-methyl-2-(o-tolyl)-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-2-(o-tolyl)-1H-benzo[d]imidazole(31815-61-9)
• EPA Substance Registry System: 1-methyl-2-(o-tolyl)-1H-benzo[d]imidazole(31815-61-9)

Safety Data

• Hazardous Substances Data: 31815-61-9(Hazardous Substances Data)

Upstream product

• 1240238-60-1 1-(2-methylphenyl)-2-propynyl acetate 
• 1632-83-3 1-Methylbenzimidazole 
• 578-58-5 2-methylmethoxybenzene 
• 25148-68-9 N-methylbenzene-1,2-diamine dihydrochloride 
• 529-20-4 2-methylphenyl aldehyde 
• 6832-87-7 2-bromo-N-methylaniline 
• 527-85-5 o-Methylbenzamid 
• 95-49-8 2-methylchlorobenzene 
• 348-54-9 2-Fluoroaniline 
• 2170-09-4 N,2-dimethylbenzamide 
• 1519051-14-9 N'-(2-fluorophenyl)-N,2-dimethylbenzimidamide 
• 18412-55-0 triethoxy(o-tolyl)silane 
• 1021397-47-6 N-methyl-N-phenyl-2-methylphenylamidine 
• 4760-34-3 N-methyl-1,2-phenylenediamine 

Relevant articles and documents

An Unexpected Formation of 2-Arylbenzimidazoles from α,α-Diiodo-α’-acetoxyketones and o-Phenylenediamines

An unusual reactivity of the α,α-diiodo-α’-acetoxyketones with o-phenylenediamines is reported through the formation of 2-arylbenzimidazoles. A systematic study through a series of fruitful control experiments and isolation of key intermediates unravelled the unprecedented domino mechanism. This process involves a stepwise two-carbon fragmentation pathway through domino and sequential amidation–aziridination–decarbonylation–I2-mediated aminative cyclization–oxidation reactions. This strategy employs no additives like oxidant, metal catalyst, bases, and represents yet another novel reactivity profile of the building blocks α,α-diiodo-α’-acetoxyketones.

Electrochemical Synthesis of Benzimidazoles via Dehydrogenative Cyclization of Amidines

The development of efficient and sustainable methodologies for the synthesis of N-heterocycles is a constant focus of organic synthesis. Herein an electrochemical method is reported for the synthesis of benzimidazoles through dehydrogenative cyclization of easily available N-aryl amidines. The reactions were conducted under simple constant current conditions in an undivided cell without need for catalysts, chemical oxidants, or additives, and produced H2 as the only theoretical byproduct.

N-Heterocyclic Carbene (NHC)-Catalyzed One-Pot Aerobic Oxidative Synthesis of 2-Substituted Benzo[ d ]oxazoles, Benzo[ d ]thiazoles and 1,2-Disubstituted Benzo[ d ]imidazoles

N-Heterocyclic carbene (NHC), generated in situ from easily available N-heterocyclic imidazolium salt with air as terminal oxidant, has successfully been utilized as a cheap and efficient catalyst for one-pot aerobic oxidative synthesis of 2-arylbenzo[ d ]oxazoles, 2-substituted benzo[ d ]thiazoles, and 1,2-disubstituted benzo[ d ]imidazoles.