31816-29-2Relevant articles and documents
Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
Burmao?lu, Serdar,Se?inti, Hatice,Mozio?lu, Erkan,G?ren, Ahmet C.,Altunda?, Ramazan,Se?en, Hasan
, p. 878 - 884 (2017)
Four multicaulin and miltirone-like phenanthrene derivatives were synthesised and evaluated as antituberculosis agents. The crucial step of the synthesis was Pschorr coupling of 4-(3-isopropyl-4-methoxyphenyl)-2-(2-aminophenyl)ethane (13) to give 2-isopro
NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND MEDICAL USE THEREOF
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Page/Page column 36, (2009/04/23)
An object of the present invention is to provide a medicament as a thyroid hormone receptor ligand which is sufficient in drug efficacy and safety, and has the excellent action as a drug. The present invention provides a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: [wherein [Chemical Formula 2] is a single bond or a double bond; A is -CH2- or -CO-; X, Y, and Z are each independently a nitrogen atom or a carbon atom; R1 is a hydrogen atom or an aralkyl group; R2 is an alkyl group or an aralkyl group, etc.; R3 is a hydrogen atom or an alkyl group, etc.; R4 is a hydrogen atom or an alkyl group; R5 is a hydrogen atom, an alkyl group or a halo lower alkyl group, etc.; R6 is a hydrogen atom or an alkyl group; R7 is a hydrogen atom, etc.; R8 is a hydrogen atom, or an alkyl group, etc.; and E is -NHCO-G-COR12, etc. (wherein G is a single bond or an alkylene group, and R12 is a hydroxy group or an alkoxy group)].
Synthesis of aromatic diterpenes synthesis of 12-hydroxy-abieta-8,11,13-trien-3,7-dione
Burnell,Caron
, p. 127 - 132 (2007/10/02)
Model studies involving cationic cyclisation of suitable dienes have provided a synthesis of the title compound. Preparation of the dienes from available aromatic starting materials and the modification of the cyclised products are described.