31821-78-0

Basic information

• Product Name: 3H-1,2,4-Triazole-3-thione, 4-amino-2,4-dihydro-5-(3,4,5-trimethoxyphenyl)-
• CAS NO: 31821-78-0
• Molecular Formula: C11H14N4O3S
• Molecular Weight: 282.323
• Mol File: 31821-78-0.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 3H-1,2,4-Triazole-3-thione, 4-amino-2,4-dihydro-5-(3,4,5-trimethoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-1,2,4-Triazole-3-thione, 4-amino-2,4-dihydro-5-(3,4,5-trimethoxyphenyl)-(31821-78-0)
• EPA Substance Registry System: 3H-1,2,4-Triazole-3-thione, 4-amino-2,4-dihydro-5-(3,4,5-trimethoxyphenyl)-(31821-78-0)

Safety Data

• Hazardous Substances Data: 31821-78-0(Hazardous Substances Data)

Upstream product

• 23269-92-3 5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole-2-thiol 
• 6178-44-5 ethyl 3,4,5-trimethoxybenzoate 
• 3291-03-0 3,4,5-trimethoxybenzohydrazide 
• 1153791-73-1 C₁₀H₁₄N₂O₄ 
• 1153263-59-2 5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole-2-thiol 
• 6395-18-2 methyl 2,3,4-trimethoxybenzoate 
• 573-11-5 2,3,4-Trimethoxy-benzoic acid 
• 67572-35-4 potassium 2-(3,4,5-trimethoxybenzoyl)hydrazinecarbodithioate 
• 75-15-0 carbon disulfide 
• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 118-41-2 Eudesmic acid 
• 2231-57-4 Thiocarbohydrazide 

Downstream Products

• 67572-55-8 6-phenyl-3-(3,4,5-trimethoxyphenyl)-7H-[1,2,4]triazolo[3,4- b][1,3,4]thiadiazine 
• 110767-36-7 6-(4-nitrophenyl)-3-(3,4,5-trimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 150535-96-9 [4-Amino-5-(3,4,5-trimethoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-acetic acid methyl ester 
• 126598-12-7 [6-(4-Chloro-phenyl)-3-(3,4,5-trimethoxy-phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]-acetic acid 
• 110767-58-3 3-(3,4,5-trimetossifenil)-4-ammino-5-carbossimetiltio-4H-1,2,4-triazolo 
• 150536-09-7 [3-(3,4,5-Trimethoxy-phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-acetic acid ethyl ester 
• 150536-12-2 4-[4-Amino-5-(3,4,5-trimethoxy-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-3-oxo-butyric acid ethyl ester 
• 126598-11-6 [6-(4-Fluoro-phenyl)-3-(3,4,5-trimethoxy-phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]-acetic acid 
• 126598-10-5 [6-Phenyl-3-(3,4,5-trimethoxy-phenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]-acetic acid 
• 22706-11-2 3-phenyl-4-amino-5-mercapto-1,2,4-triazole 
• 80987-63-9 5,5'-(ditiobis)-3-(3,4,5-trimetossifenil)-4H-1,2,4-triazolo 

Relevant articles and documents

Design, synthesis and biological evaluation of novel 1,2,4-triazolo [3,4-b][1,3,4] thiadiazines bearing furan and thiophene nucleus

Twenty-six novel 1,2,4-triazolo [3,4-b][1,3,4] thiadiazines containing furan and thiophene nucleus were designed, synthesized and evaluated for their antiproliferative activities. The results indicated that most of the compounds showed moderate to potent antiproliferative activities against four cancer cell lines, PC-3, HepG2, A549, and MCF-7. Particularly, compound 32 showed eleven-, three-, and two-fold improvement compared to positive control fluorouracil in inhibiting HepG2, PC-3, and A549 cell proliferation with IC50 values of 5.09, 3.70 and 12.74 μM, respectively. Further flow-activated cell sorting analysis revealed that the most promising compound 32 displayed a significant effect on G2/M cell-cycle arrest in a dose-dependent manner in PC-3 cells. These encouraging results should provide important information for the development of new anticancer agents.

HCK INHIBITORS FOR THE TREATMENT OF FIBROSIS AND CANCER

Compounds which are thiazole and triazole derivatives are disclosed, including compounds of the following genus: Formula I. The compounds are inhibitors of hematopoietic cell kinase (HCK) and exhibit anti-fibrotic and anti-proliferative effects. They are useful in the treatment of a variety of disorders, including a fibrosis or a fibrotic disease, such as renal fibrosis.

Synthesis and antitumor evaluation of novel fused heterocyclic 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives

In this study, twenty three 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives were synthesized and their antiproliferative activities in vitro were studied against SMMC-7721, HeLa, A549, and L929 by the CCK-8 assay. The bioassay results demonstrated that all tested compounds 8(a–w) exhibited antiproliferation with different degrees, and some compounds showed better effects than reference drug 5-fluorouracil. Among these screened compounds, compounds 8a, 8d, and 8l displayed significant antitumor activities in inhibiting SMMC-7721cell proliferation with IC50 values of 1.64, 1.74, and 1.61 μM, respectively. Compounds 8d and 8l were manifested highly effective biological activity versus HeLa cells with IC50 values of 2.23 and 2.84 μM, respectively. Compound 8l was found to have the highest antitumor potency against A549 cells with IC50 value of 2.67 μM. Furthermore, all compounds exhibited weaker cytotoxic effects than 5-fluorouracil on normal cell lines L929.