318237-73-9 Usage
Description
2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine is a chemical compound that is an impurity found in Conivaptan (C384700), a medication used for the treatment of congestive heart failure.
Uses
Used in Pharmaceutical Industry:
2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine is used as an impurity in Conivaptan, which is a medication for the treatment of congestive heart failure. Its presence in Conivaptan may have implications for the drug's safety and efficacy, and efforts are made to minimize its levels during the manufacturing process.
Check Digit Verification of cas no
The CAS Registry Mumber 318237-73-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,8,2,3 and 7 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 318237-73:
(8*3)+(7*1)+(6*8)+(5*2)+(4*3)+(3*7)+(2*7)+(1*3)=139
139 % 10 = 9
So 318237-73-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H13N3/c1-8-14-11-6-7-13-10-5-3-2-4-9(10)12(11)15-8/h2-5,13H,6-7H2,1H3,(H,14,15)
318237-73-9Relevant articles and documents
VASOPRESSIN V1A ANTAGONISTS
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Page/Page column 36, (2008/06/13)
The present invention concerns compounds inter alia according to general formula 1a. Compounds according to the invention are vasopressin V 1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment of dysmenorrhoea.
A new synthetic route to YM087, an arginine vasopressin antagonist
Tsunoda, Takashi,Tanaka, Akihiro,Mase, Toshiyasu,Sakamoto, Shuichi
, p. 1113 - 1122 (2007/10/03)
A new synthesis of N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl} biphenyl-2-carboxamide monohydrochloride (1, YM087) via new imidazobenzazepine intermediates is described. This method remarkably improves the overall yiel