31858-66-9Relevant articles and documents
Synthesis of mycophenolate Mofetil-[14C], RS-61443-14C
Huang,Parnes
, p. 449 - 456 (1995)
Synthesis of the potent immunosuppressive agent, mycophenolate mofetil (1) labelled with carbon-14 is described. Methoxyethoxymethyl (MEM) protected mycophenolate norbromide (9) was prepared from unlabelled mycophenolic acid (2) using a modified Hunsdiecker reaction. A three step synthesis furnished the title compound, having a specific activity of 53.8 mCi/mmol, in 49.5% overall yield from K14CN.
Seden et al.
, p. 4915,4917 (1969)
Phosphamide derivative as well as preparation method and application thereof
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Paragraph 0676; 0679-0684, (2019/02/19)
The invention relates to a compound of a general formula (I), a stereoisomer or pharmaceutically acceptable salt of the compound and application of the compound in preparation of medicines for preventing or treating diabetes, resisting tumors, preventing or treating attention deficit hyperactivity disorder and motor neuron diseases, protecting brain and preventing or treating central nervous system related diseases, immunosuppression, organ tissue or cell allogeneic suppression rejection reaction, immune regulation and/or inflammatory diseases, convulsions, epilepsy or cerebral apoplexy. The structure of the compound of the general formula (I) is Q-L-R, and the groups of the compound are defined in the specification.
Diels-Alder and Stille Coupling Approach for the Short Protecting-Group-Free Synthesis of Mycophenolic Acid, Its Phenylsulfenyl and Phenylselenyl Analogues, and Reactive Oxygen Species (ROS) Probing Capacity in Water
Halle, Mahesh B.,Yudhistira, Tesla,Lee, Woo-Hyun,Mulay, Sandip V.,Churchill, David G.
, p. 3557 - 3561 (2018/06/26)
A short, protecting-group-free synthesis is achieved. The synthesis is step-efficient and general. A Diels-Alder and Stille cross-coupling approach includes key transformations, allowing for a competitive synthesis which involves a rare halophenol Stille cross-coupling study. The phenylselenyl and phenylsulfenyl analogues were prepared as novel compounds in good overall yield. The applicability of one of the intermediates as a potential probe for reactive oxygen species (ROS) in water is investigated.